Fluorination of amino alcohols and hydroxyaziridines by Olah's reagent.

Gerard Alvernhe , Sylvie Lacombe-Lhoste (1) , André Laurent , Christine. Rousset

1 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

Treatment of α,β-amino alcs. with Olah's reagent (pyridine, 10HF) gave the corresponding α,β-fluoro amines. E.g., reaction of PhC(OH)MeCMe2NH2 with Olah's reagent in CH2Cl2 at 20° for 48 h gave 82% PhCFMeCMe2NH2. Fluoro hydroxy amines, fluoroaziridines, and difluoro amines were prepd. by the action of this reagent on α-hydroxy aziridines. [on SciFinder(R)]

Mots clés: aziridine hydroxy fluorination Olah reagent; fluorination amino alc hydroxyaziridine Olah reagent; fluoro amine; fluoroaziridine

Domaines: Chimie

Gerard Alvernhe, Sylvie Lacombe-Lhoste, André Laurent, Christine. Rousset. Fluorination of amino alcohols and hydroxyaziridines by Olah's reagent.. Journal of Chemical Research, 1983, Copyright (C) 2017 American Chemical Society (ACS). All Rights Reserved., pp.246--7. ⟨hal-01587178⟩