Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model

Pauline Marangoni; Cyril Charles; Paul Tafforeau; Virginie Laugel-Haushalter; Adriane Joo; Agnes Bloch-Zupan; Ophir D. Klein; Laurent Viriot

doi:10.1038/srep11658

Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model

Pauline Marangoni ¹ Cyril Charles ¹ Paul Tafforeau ² Virginie Laugel-Haushalter ³ Adriane Joo ^{4, 5} Agnes Bloch-Zupan ^{6, 7, 3} Ophir D. Klein ^{4, 8, 9, 5} Laurent Viriot ¹

1 IGFL - Institut de Génomique Fonctionnelle de Lyon

2 ESRF - European Synchrotron Radiation Facility

3 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

4 Univ Calif San Francisco, Dept Orofacial Sci, San Francisco, CA 94143 USA

5 Univ Calif San Francisco, Program Craniofacial Biol, San Francisco, CA 94143 USA

6 Faculté dentaire, Université de Strasbourg

7 Reference Centre for Oro-dental Manifestations of Rare Diseases

8 Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

9 Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

Abstract : The question of phenotypic convergence across a signalling pathway has important implications for both developmental and evolutionary biology. The ERK-MAPK cascade is known to play a central role in dental development, but the relative roles of its components remain unknown. Here we investigate the diversity of dental phenotypes in Spry2(-/-), Spry4(-/-), and Rsk2(-/Y) mice, including the incidence of extra teeth, which were lost in the mouse lineage 45 million years ago (Ma). In addition, Sprouty-specific anomalies mimic a phenotype that is absent in extant mice but present in mouse ancestors prior to 9 Ma. Although the mutant lines studied display convergent phenotypes, each gene has a specific role in tooth number determination and crown patterning. The similarities found between teeth in fossils and mutants highlight the pivotal role of the ERK-MAPK cascade during the evolution of the dentition in rodents

Type de document :

Article dans une revue

Scientific Reports, Nature Publishing Group, 2015, 5, 12 p. 〈10.1038/srep11658〉

Domaine :

Planète et Univers [physics] / Sciences de la Terre

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