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Journal articles
Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model
Abstract : The question of phenotypic convergence across a signalling pathway has important implications for both developmental and evolutionary biology. The ERK-MAPK cascade is known to play a central role in dental development, but the relative roles of its components remain unknown. Here we investigate the diversity of dental phenotypes in Spry2(-/-), Spry4(-/-), and Rsk2(-/Y) mice, including the incidence of extra teeth, which were lost in the mouse lineage 45 million years ago (Ma). In addition, Sprouty-specific anomalies mimic a phenotype that is absent in extant mice but present in mouse ancestors prior to 9 Ma. Although the mutant lines studied display convergent phenotypes, each gene has a specific role in tooth number determination and crown patterning. The similarities found between teeth in fossils and mutants highlight the pivotal role of the ERK-MAPK cascade during the evolution of the dentition in rodents
Cited literature [55 references]
https://hal.archives-ouvertes.fr/hal-01572830
Contributor : Colette Orange <>
Submitted on : Tuesday, August 8, 2017 - 11:56:28 AM
Last modification on : Tuesday, March 17, 2020 - 2:15:56 AM
Contributor : Colette Orange <>
Submitted on : Tuesday, August 8, 2017 - 11:56:28 AM
Last modification on : Tuesday, March 17, 2020 - 2:15:56 AM
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