A multiscale modelling approach for the regulation of the cell cycle by the circadian clock

Raouf El Cheikh 1 Samuel Bernard 2, 3 Nader El Khatib 4
1 SMARTc
CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
2 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
CGMC - Centre de génétique moléculaire et cellulaire, Inria Grenoble - Rhône-Alpes, ICJ - Institut Camille Jordan [Villeurbanne], UCBL - Université Claude Bernard Lyon 1 : EA
Abstract : We present a multiscale mathematical model for the regulation of the cell cycle by the circadian clock. Biologically, the model describes the proliferation of a population of heterogeneous cells connected to each other. The model consists of a high dimensional transport equation structured by molecular contents of the cell cycle-circadian clock coupled oscillator. We propose a computational method for resolution adapted from the concept of particle methods. We study the impact of molecular dynamics on cell proliferation and show an example where discordance of division rhythms between population and single cell levels is observed. This highlights the importance of multiscale modeling where such results cannot be inferred from considering solely one biological level.
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Journal of Theoretical Biology, Elsevier, 2017, 426, pp.117-125. 〈10.1016/j.jtbi.2017.05.021〉
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Raouf El Cheikh, Samuel Bernard, Nader El Khatib. A multiscale modelling approach for the regulation of the cell cycle by the circadian clock. Journal of Theoretical Biology, Elsevier, 2017, 426, pp.117-125. 〈10.1016/j.jtbi.2017.05.021〉. 〈hal-01561617〉

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