Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons

Elsa Isingrini , Lea Perret , Quentin Rainer , Benedicte Amilhon , Elisa Guma , Arnaud Tanti , Garance Martin , Jennifer Robinson , Luc Moquin , Fabio Marti (1) , Naguib Mechawar , Sylvain Williams , Alain Gratton , Bruno Giros

1 NPS-06 - Neurophysiologie et comportements = Neurophysiology and Behavior

Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.

Domaines: Neurosciences [q-bio.NC]

Elsa Isingrini, Lea Perret, Quentin Rainer, Benedicte Amilhon, Elisa Guma, et al.. Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. Nature Neuroscience, 2016, 19 (4), pp.560+. ⟨10.1038/nn.4245⟩. ⟨hal-01542253⟩