In vivo evaluation of radiofluorinated caspases-3/7 inhibitors as radiotracers for apoptosis imaging and comparison with [18F]-ML-10 in a stroke model in the rat

M Médoc (1, 2) , M Dhilly (1, 2) , L Matesic (3) , J Toutain (2) , Am Krause-Heuer (3) , J Delamare (1, 2) , Bh Fraser (3) , O Touzani (2) , Louisa Barré (1, 2) , I Greguric (3) , . Sobrio F (1, 2)

1 LDM-TEP - Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons
2 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales
3 Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia

Mots clés: Fluorine-18; PET; Apoptosis; Isatins; Cerebral stroke; In vivo evaluation; Caspase-3 inhibitors; Ischemia

Domaines: Sciences du Vivant [q-bio]

M Médoc, M Dhilly, L Matesic, J Toutain, Am Krause-Heuer, et al.. In vivo evaluation of radiofluorinated caspases-3/7 inhibitors as radiotracers for apoptosis imaging and comparison with [18F]-ML-10 in a stroke model in the rat. Molecular Imaging and Biology, 2016, 18, pp.117-128. ⟨10.1007/s11307-015-0865-1⟩. ⟨hal-01538309⟩