Whole genome analysis of a schistosomiasis-transmitting freshwater snail

C. Adema 1 L. Hillier 2 C. Jones 3 E.S. Loker 1 M. Knight 4, 5 P. Minx 2 G. Oliveira 6 N. Raghavan 7 A. Shedlock 8 L. Amaral 9 H. Arican-Goktas 10 J. Assis 6 E. Baba 6 O. Baron 11 C. Bayne 12 Utibe Bickham-Wright 13 Kyle K. Biggar 14 M.S. Blouin 12 B. Bonning 15 Chris Botka 16 J. Bridger 10 K. Buckley 17 S. Buddenborg 1 R. Caldeira 6 J. Carleton 18 O. Carvalho 6 M. Castillo 19 I. Chalmers 20 M. Christensens 21 S. Clifton 2 Céline Cosseau 22 Christine Coustau 11 R. Cripps 19 Y. Cuesta-Astroz 6 S. Cummins 23 L. Di Stefano 24 N. Dinguirard 13 David Duval 22 S. Emrich 25 Cédric Feschotte 18 René Feyereisen 11, 26 P. Fitzgerald 27 Catrina Fronick 2 L. Fulton 2 Richard Galinier 22 Sandra G. Gava 6 M. Geusz 28 Kathrin K. Geyer 29 G.I. Giraldo-Calderón 25 Matheus de Souza Gomes 9 M. Gordy 28 Benjamin Gourbal 22 Christoph Grunau 22 P. Hanington 30 K.F. Hoffmann 29 D. Hughes 21 J. Humphries 31 Daniel J. Jackson 32 Liana K. Jannotti-Passos 6 Wander de Jesus Jeremias 6 Susan Jobling 33 Bishoy Kamel 34 Aurélie Kapusta 18 Satwant Kaur 33 Joris M Koene 35 Andrea B. Kohn 36 Dan Lawson 21 Scott P. Lawton 37 Di Liang 38 Yanin Limpanont 23 Sijun Liu 15 Anne E. Lockyer 33 Tyanna L. Lovato 19 Fernanda Ludolf 6 Vince Magrini 2 Donald P Mcmanus 39 Mónica Medina 40 Milind Misra 1 Guillaume Mitta 22 Gerald M. Mkoji 41 Michael J. Montague 42 Cesar Montelongo 19 Leonid L. Moroz 36 Monica Muñoz-Torres 43 Umar Niazi 20 Leslie Noble 3 Francislon S. Oliveira 6 Fabiano S. Pais 6 Anthony T. Papenfuss 24, 44 Rob Peace 45 Janeth J. Pena 1 Emmanuel A. Pila 30 Titouan Quelais 22 Brian J Raney 46 Jonathan P Rast 17 David Rollinson 47 Izinara C. Rosse 6 Bronwyn Rotgans 1 Edwin J. Routledge 10 Kathryn M. Ryan 1 Larissa L.S. Scholte, 6 K. Storey 14 Martin Swain 20 J.A. Tennessen 12 C. Tomlinson 2 David Trujillo 1 E. Volpi 48 A.J. Walker 49 T. Wang 38 I. Wannaporn 1 W. Warren 1 X.J. Wu 1 T.P. Yoshino 1 M. Yusuf 1 S.M. Zhang 1 M. Zhao 1 R. Wilson 1
Abstract : Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis
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C. Adema, L. Hillier, C. Jones, E.S. Loker, M. Knight, et al.. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, Nature Publishing Group, 2017, 8, pp.15451. ⟨https://www.nature.com/articles/ncomms15451⟩. ⟨10.1038/ncomms15451⟩. ⟨hal-01523953⟩

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