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Whole genome analysis of a schistosomiasis-transmitting freshwater snail

C. Adema 1 L. Hillier 2 C. Jones 3 E.S. Loker 1 M. Knight 4, 5 P. Minx 2 G. Oliveira 6 N. Raghavan 7 A. Shedlock 8 L. Amaral 9 H. Arican-Goktas 10 J. Assis 6 E. Baba 6 O. Baron 11 C. Bayne 12 Utibe P Bickham-Wright 13 Kyle K. Biggar 14 M.S. Blouin 12 B. Bonning 15 Chris Botka 16 J. Bridger 10 K. Buckley 17 S. Buddenborg 1 R. Caldeira 6 J. Carleton 18 O. Carvalho 6 M. Castillo 19 I. Chalmers 20 M. Christensens 21 S. Clifton 2 Céline Cosseau 22 Christine Coustau 11 R. Cripps 19 Y. Cuesta-Astroz 6 S. Cummins 23 L. Di Stefano 24 N. Dinguirard 13 David Duval 22 S. Emrich 25 Cédric Feschotte 18 René Feyereisen 11, 26 P. Fitzgerald 27 Catrina Fronick 2 L. Fulton 2 Richard Galinier 22 Sandra G. Gava 6 M. Geusz 28 Kathrin K. Geyer 20 G.I. Giraldo-Calderón 25 Matheus de Souza Gomes 9 M. Gordy 28 Benjamin Gourbal 22 Christoph Grunau 22 P. Hanington 29 K.F. Hoffmann 20 D. Hughes 21 J. Humphries 30 Daniel J. Jackson 31 Liana K. Jannotti-Passos 6 Wander de Jesus Jeremias 6 Susan Jobling 32 Bishoy Kamel 33 Aurélie Kapusta 18 Satwant Kaur 32 Joris M Koene 34 Andrea B. Kohn 35 Dan Lawson 21 Scott P. Lawton 36 Di Liang 37 Yanin Limpanont 23 Sijun Liu 15 Anne E. Lockyer 32 Tyanna L. Lovato 19 Fernanda Ludolf 6 Vince Magrini 2 Donald P Mcmanus 38 Mónica Medina 39 Milind Misra 1 Guillaume Mitta 22 Gerald M. Mkoji 40 Michael J. Montague 41 Cesar Montelongo 19 Leonid L. Moroz 35 Monica Muñoz-Torres 42 Umar P Niazi 20 Leslie Noble 3 Francislon S. Oliveira 6 Fabiano S. Pais 6 Anthony T. Papenfuss 24, 43 Rob Peace 44 Janeth J. Pena 1 Emmanuel A. Pila 29 Titouan Quelais 22 Brian J B. J. Raney 45 Jonathan P Rast 17 David Rollinson 46 Izinara C. Rosse 6 Bronwyn Rotgans 1 Edwin J. Routledge 10 Kathryn M. Ryan 1 Larissa L.S. Scholte, 6 K. Storey 14 Martin Swain 20 J.A. Tennessen 12 C. Tomlinson 2 David Trujillo 1 E. Volpi 47 A.J. Walker 48 T. Wang 37 I. Wannaporn 1 W. Warren 1 X.J. Wu 1 T.P. Yoshino 1 M. Yusuf 1 S.M. Zhang 1 M. Zhao 1 R. Wilson 1 
Abstract : Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis
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C. Adema, L. Hillier, C. Jones, E.S. Loker, M. Knight, et al.. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, 2017, 8, pp.15451. ⟨10.1038/ncomms15451⟩. ⟨hal-01523953⟩

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