Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms

Pauline Delaveau (1) , Tiago Arruda Sanchez (2) , Ricardo Steffen (3) , Karine Deschet (4) , Maritza Jabourian (4) , Vincent Perlbarg (5, 6) , Emerson Leandro Gasparetto (2) , Stéphanie Dubal (1) , Jorge Costa E Silva (7, 8) , Philippe Fossati (1)

1 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
2 UFRJ - Universidade Federal do Rio de Janeiro [Brasil] = Federal University of Rio de Janeiro [Brazil] = Université fédérale de Rio de Janeiro [Brésil]
3 Hospital Santa Casa de Misericórdia do Rio de Janeiro
4 IRIS - Institut de Recherches Internationales Servier [Suresnes]
5 LIB - Laboratoire d'Imagerie Biomédicale [Paris]
6 NeurATRIS - IHU-A-ICM - Institut de neurosciences translationnelles de Paris
7 PUC-Rio - Pontifícia Universidade Católica do Rio de Janeiro [Brasil] = Pontifical Catholic University of Rio de Janeiro [Brazil] = Université catholique pontificale de Rio de Janeiro [Brésil]
8 INBRACER - Instituto Brasileiro do Cérebro

Clinical remission of depression may be associated with emotional residual symptoms. We studied the association of emotional blunting, rumination with neural networks dynamics in remitted depressed patients and cognitive performance during an N-Back task. Twenty-six outpatients in remission of depression (Hamilton Depressive rating scale score <7) performed an N-Back task during fMRI assessment. All patients had been treated by paroxetine for a minimum of 4 months. Two subgroups of patients [Nonemotionally blunted (NEB) = 14 and emotionally blunted (EB) = 12] were determined. To identify functional network maps across participants, the Network Detection using Independent Component Analysis approach was employed. Within and between Task Positive Network (TPN) and Default Mode Network (DMN) connectivity were assessed and related to variability of performance on the N-Back task and rumination. EB and NEB patients were not different for the level of accurate responses at the N-Back. However over the entire working memory task, the negative correlation between DMN and TPN was significantly lower in the EB than NEB group and was differently related to cognitive performance and rumination. The stronger the negative correlation between DMN and TPN was, the less variable the reaction time during 3-Back task in NEB patients. Moreover the greater the negative correlation between DMN and TPN was, the lower the rumination score in EB patients. Emotional blunting may be associated with compromised monitoring of rumination and cognitive functioning in remitted depressed patients through altered cooperation between DMN and TPN. The study suggests clinical remission in depression is associated with biological heterogeneity.

Mots clés: working memory; depressive disorder; neural networks; fMRI; task performance

Domaines: Sciences cognitives; Psychiatrie et santé mentale

Pauline Delaveau, Tiago Arruda Sanchez, Ricardo Steffen, Karine Deschet, Maritza Jabourian, et al.. Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms. Human Brain Mapping, 2017, ⟨10.1002/hbm.23603⟩. ⟨hal-01520364⟩