(Epi)genetic inheritance in Schistosoma mansoni: a system approach

Abstract : The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
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Submitted on : Thursday, April 20, 2017 - 12:03:01 PM
Last modification on : Wednesday, May 29, 2019 - 11:40:04 AM

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Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin K. Geyer, Karl F. Hoffmann, et al.. (Epi)genetic inheritance in Schistosoma mansoni: a system approach. Trends in Parasitology, Elsevier, 2017, 1590, pp.285-294. ⟨http://www.cell.com/trends/parasitology/fulltext/S1471-4922(16)30224-0⟩. ⟨10.1016/j.pt.2016.12.002⟩. ⟨hal-01511049⟩

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