Translation regulator ballet in meiotic spindle

Abstract : The fine spatial and temporal resolution of translation control can have a rapid and subtle effect on the microenvironment of the cell in comparison with transcriptional regulation. Mammalian oocyte represents a relevant model that allows addressing the spatial control of translation during meiotic maturation. The fully-grown mammalian oocyte is transcriptionally quiescent and stored maternal RNAs are used for the completion of meiosis and early embryo development. It was shown three decades ago that during resumption of meiosis, protein synthesis is not necessary for the nuclear envelope breakdown (NEBD) but active protein synthesis is required for the correct formation of the meiotic spindle and progression to metaphase II (1). Therefore mammalian oocyte represents a suited system to address translation control in relation with the cell cycle in general and with the spindle formation in particular. In this issue of the Cell Cycle the study by Jansova et al. gains new insight into the role of the eukaryotic initiation factor 4E-Binding Protein 1 (4E-BP1) in the meiotic spindle formation in mouse oocyte (2).
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Cell Cycle, Taylor & Francis, 2017, 〈10.1080/15384101.2017.1304732〉
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Soumis le : jeudi 23 mars 2017 - 14:44:27
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Patrick Cormier. Translation regulator ballet in meiotic spindle. Cell Cycle, Taylor & Francis, 2017, 〈10.1080/15384101.2017.1304732〉. 〈hal-01494440〉



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