Graph Theory-Based Brain Connectivity for Automatic Classification of Multiple Sclerosis Clinical Courses

Gabriel Kocevar (1) , Claudio Stamile (1) , Salem Hannoun (1) , François Cotton (1, 2) , Sandra Vukusic (3) , Françoise Durand-Dubief (3, 1) , Dominique Sappey-Marinier (4, 1)

1 RMN et optique : De la mesure au biomarqueur
2 HCL - Hospices Civils de Lyon
3 Service de Neurologie [Lyon]
4 CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant

Purpose: In this work, we introduce a method to classify Multiple Sclerosis (MS) patients into four clinical profiles using structural connectivity information. For the first time, we try to solve this question in a fully automated way using a computer-based method. The main goal is to show how the combination of graph-derived metrics with machine learning techniques constitutes a powerful tool for a better characterization and classification of MS clinical profiles.] along with 26 healthy controls (HC) underwent MR examination. T1 and diffusion tensor imaging (DTI) were used to obtain structural connectivity matrices for each subject. Global graph metrics, such as density and modularity, were estimated and compared between subjects' groups. These metrics were further used to classify patients using tuned Support Vector Machine (SVM) combined with Radial Basic Function (RBF) kernel. Results: When comparing MS patients to HC subjects, a greater assortativity, transitivity, and characteristic path length as well as a lower global efficiency were found. Using all graph metrics, the best F-Measures (91.8, 91.8, 75.6, and 70.6%) were obtained for binary (HC-CIS, CIS-RR, RR-PP) and multi-class (CIS-RR-SP) classification tasks, respectively. When using only one graph metric, the best F-Measures (83.6, 88.9, and 70.7%) were achieved for modularity with previous binary classification tasks. Conclusion: Based on a simple DTI acquisition associated with structural brain connectivity analysis, this automatic method allowed an accurate classification of different MS patients' clinical profiles.

Mots clés: Kocevar et al; multiple sclerosis; SVM; structural connectivity; diffusion tensor imaging; MRI; graph theory; classification; MS Phenotype Classification Using Connectome

Domaines: Imagerie; Neurosciences [q-bio.NC]

Gabriel Kocevar, Claudio Stamile, Salem Hannoun, François Cotton, Sandra Vukusic, et al.. Graph Theory-Based Brain Connectivity for Automatic Classification of Multiple Sclerosis Clinical Courses. Frontiers in Neuroscience, 2016, 10, pp.478. ⟨10.3389/fnins.2016.00478⟩. ⟨hal-01492694⟩