Delivery of SiC-based nanoparticles into live cells driven by cell-penetrating peptides SAP and SAP-E

T. Serdiuk (1, 2) , I. Bakanovich , Vladimir Lysenko (3) , S. Alekseev (2) , V. Skryshevsky , S. Afonin (4) , Eric Berger (1) , Alain Geloen (1) , I. Komarov (2)

1 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
2 Taras Shevchenko National University of Kyiv
3 INL - S&N - INL - Spectroscopies et Nanomatériaux
4 KIT - Karlsruher Institut für Technologie

The delivery of SiC-based nanoparticles (SiC-NPs) into living eukaryotic cells is facilitated in the presence of cell-penetrating peptides, both cationic (SAP) and anionic (SAP-E). The SiC-NP surface functional group modification combined with rational CPP selection introduces an additional mode of delivery control.

Domaines: Matériaux; Pharmacie galénique

T. Serdiuk, I. Bakanovich, Vladimir Lysenko, S. Alekseev, V. Skryshevsky, et al.. Delivery of SiC-based nanoparticles into live cells driven by cell-penetrating peptides SAP and SAP-E. RSC Advances, 2015, 5 (26), pp.20498-20502. ⟨10.1039/C4RA10688A⟩. ⟨hal-01489394⟩