Free and accessible knowledge

Journal articles

Novel genetic loci associated with hippocampal volume

Derrek P. Hibar ^{1, 2} Hieab H. H. Adams ^{3, 2} Neda Jahanshad ^{1, 2} Ganesh Chauhan ^{4, 2} Jason L. Stein ^{5, 2} Edith Hofer ^{5, 2} Miguel E. Renteria ^{6, 2} Joshua C. Bis ^{7, 2} Alejandro Arias-Vasquez ^{8, 9, 2} M. Kamran Ikram ² Sylvane Desrivières ^{10, 2} Meike W. Vernooij ² Lucija Abramovic ^{11, 2} Saud Alhusaini ^{12, 13, 2} Najaf Amin ^{14, 2} Micael Andersson ^{15, 2} Konstantinos Arfanakis ^{16, 17, 2} Benjamin S. Aribisala ^{18, 19, 2} Nicola J. Armstrong ^{20, 2} Lavinia Athanasiu ^{21, 2} Tomas Axelsson ^{22, 2} Ashley H. Beecham ^{23, 2} Alex Beiser ^{24, 25, 2} Manon Bernard ²⁶ Susan H. Blanton ^{27, 2} Marc Bohlken ^{11, 2} Marco Boks ^{11, 2} Janita Bralten ^{28, 29, 2} Adam M. Brickman ^{5, 2} Owen Carmichael ^{30, 2} M. Mallar Chakravarty ^{31, 2} Qiang Chen ^{5, 2} Christopher Ching ^{5, 2} Vincent Chouraki ^{32, 2, 33} Gabriel Cuellar-Partida ^{6, 2} Fabrice Crivello ^{34, 2} Anouk den Braber ^{5, 2} Nhat Trung Doan ² Stefan Ehrlich ^{35, 2} Sudheer Giddaluru ^{21, 36, 2} Aaron L. Goldman ^{37, 2} Rebecca F. Gottesman ^{38, 2} Oliver Grimm ^{5, 2} Michael E. Griswold ^{5, 2} Tulio Guadalupe ^{39, 40, 2} Boris A. Gutman ^{41, 42, 2} Johanna Hass ^{43, 2} Unn K. Haukvik ^{21, 2} David Hoehn ^{5, 2} Avram J. Ho ^{44, 2} Martine Hoogman ^{5, 2} Deborah Janowitz ^{45, 2} Tianye Jia ^{46, 2} Kjetil N. Jørgensen ^{47, 2} Nazanin Karbalai ^{5, 2} Dalia Kasperaviciute ^{48, 49, 2} Sungeun Kim ² Marieke Klein ^{50, 2} Bernd Kraemer ^{51, 2} Phil H. Lee ^{5, 2} David C. Liewald ^{18, 2} Lorna M. Lopez ² Michelle Luciano ^{52, 2} Christine Macare ^{10, 2} André F. Marquand ² Mar Matarin ^{53, 2} Karen A. Mather ^{54, 2} Manuel Mattheisen ^{55, 56, 57, 2} David Mckay ² Yuri Milaneschi ^{58, 2} Susana Muñoz Maniega ² Kwangsik Nho ^{59, 60, 2} Allison C. Nugent ^{61, 2} Paul Nyquist ^{62, 2} Loes M. Olde Loohuis ² Jaap Oosterlaan ² Martina Papmeyer ² Lukas Pirpamer ² Benno Pütz ^{63, 2} Adaikalavan Ramasamy ^{64, 2} Jennifer S. Richards ² Shannon L. Risacher ^{59, 60, 2} Robert Roiz-Santiañez ^{65, 2} Nanda Rommelse ^{66, 29, 2} Stefan Ropele ^{67, 2} Emma Rose ^{68, 2} Natalie A. Royle ² Tatjana Rundek ² Philipp G. Sämann ^{69, 2} Arvin Saremi ² Claudia L. Satizabal ^{70, 2} Lianne Schmaal ^{58, 2} Andrew Schork ^{71, 72, 2} Li Shen ^{73, 2} Jean Shin ² Elena Shumskaya ^{5, 2} Albert Smith ^{74, 2} Emma Sprooten ^{75, 2} Lachlan T. Strike ^{76, 77, 78, 2} Alexander Teumer ² Diana Tordesillas-Gutierrez ² Roberto Toro ^{79, 2} Daniah Trabzuni ^{80, 81, 2} Stella Trompet ² Dhananjay Vaidya ² Jeroen van Der Grond ^{82, 2} Sven van Der Lee ² Dennis van Der Meer ^{83, 2} Marjolein M. J. van Donkelaar ^{28, 29, 2} Kristel R. van Eijk ^{11, 2} Theo G. M. van Erp ^{84, 2} Daan van Rooij ^{85, 2} Esther Walton ^{86, 2} Lars Westlye ^{21, 87, 2} Christophe Whelan ^{1, 2} Beverly G. Windham ^{21, 2} Anderson M. Winkler ² Katharina Wittfeld ^{45, 88, 2} Girma Woldehawariat ^{89, 2} Christiane Wolf ² Thomas Wolfers ^{5, 2} Lisa R. Yanek ² Jingyun Yang ² Alex Zijdenbos ^{90, 2} Marcel Zwiers ^{29, 2} Ingrid Agartz ^{91, 2} Laura Almasy ^{92, 2} David Ames ^{93, 2} Philippe Amouyel ^{94, 2, 33} Ole A Andreassen ² Sampath Arepalli ^{95, 2} Amelia A. Assareh ² Sandra Barral ² Mark Bastin ^{18, 2} Diane M. Becker ² James T. Becker ² David A. Bennett ^{96, 2} John Blangero ^{97, 98, 2} Hans van Bokhoven ^{99, 2} Dorret I. Boomsma ² Henry Brodaty ^{100, 101, 2} Rachel M. Brouwer ^{102, 2} Han G. Brunner ² Randy L. Buckner ^{103, 2} Jan K. Buitelaar ^{29, 2} Kazima B. Bulayeva ^{104, 2} Wiepke Cahn ^{105, 2} Vince D. Calhoun ^{106, 107, 2} Dara M. Cannon ^{108, 2} Gianpiero L. Cavalleri ^{109, 2} Ching-Yu Cheng ^{110, 2} Sven Cichon ^{55, 56, 111, 112, 2} Mark Cookson ^{113, 2} Aiden Corvin ^{114, 115, 2} Benedicto Crespo-Facorro ^{65, 2} Joanne E. Curran ² Michael Czisch ^{116, 2} Anders M. Dale ² Gareth E. Davies ^{117, 2} Anton J. M. de Craen ² Eco J. C. de Geus ² Philip L. de Jager ^{118, 119, 120, 2} Greig I. de Zubicaray ^{121, 2} Ian Deary ² Stéphanie Debette ^{122, 2} Charles Decarli ² Norman Delanty ^{13, 123, 2} Chantal Depondt ^{124, 2} Anita Destefano ^{25, 2} Allissa Dillman ^{125, 2} Srdjan Djurovic ² Gary Donohoe ^{114, 108, 2} Wayne C. Drevets ^{108, 2} Ravi Duggirala ^{97, 2} Thomas Dyer ^{97, 98, 2} Christian Enzinger ² Susanne Erk ^{126, 2} Thomas Espeseth ^{21, 87, 2} Iryna O. Fedko ^{127, 2} Guillén Fernández ^{128, 2} Luigi Ferrucci ^{5, 2} Simon Fisher ^{129, 2} Debra A. Fleischman ^{17, 130, 2} Ian Ford ^{131, 2} Myriam Fornage ^{132, 98, 2} Tatiana M. Foroud ^{133, 2} Peter Fox ^{134, 2} Clyde Francks ^{29, 39, 2} Masaki Fukunaga ^{135, 2} J. Raphael Gibbs ^{136, 2} David C. Glahn ^{75, 2} Randy L. Gollub ^{137, 2} Harald H. H. Göring ^{138, 2} Robert Green ^{139, 2} Oliver Gruber ² Vilmundur Gudnason ^{140, 141, 2} Sebastian Guelfi ^{80, 2} Asta K. Håberg ² Narelle K. Hansell ^{52, 2} John Hardy ^{2, 142} Catharina A. Hartman ^{52, 2} Ryota Hashimoto ² Katrin Hegenscheid ^{45, 2} Andreas Heinz ² Stephanie Le Hellard ^{21, 36, 2} Dena G. Hernandez ² Dirk J. Heslenfeld ^{45, 2} Beng-Choon Ho ^{143, 2} Pieter J. Hoekstra ^{144, 2} Wolfgang Hoffmann ² Albert Hofman ² Florian Holsboer ^{145, 2} Georg Homuth ^{146, 2} Norbert Hosten ^{45, 2} Jouke-Jan Hottenga ² Matthew Huentelman ^{147, 2} Hilleke E. Hulshoff Pol ² Masashi Ikeda ² Clifford R. Jack Jr ² Mark Jenkinson ^{148, 2} Robert Johnson ^{149, 150, 2} Erik G. Jönsson ^{151, 2} J. Wouter Jukema ² René S. Kahn ^{152, 2} Ryota Kanai ^{153, 154, 2} Iwona Kloszewska ^{155, 2} David S. Knopman ^{156, 2} Peter Kochunov ^{157, 2} John B. Kwok ^{158, 2} Stephen M. Lawrie ^{18, 2} Hervé Lemaître ^{159, 2} Xinmin Liu ² Dan L. Longo ^{160, 2} Oscar L. Lopez ² Simon Lovestone ^{161, 2} Oliver Martinez ² Jean-Luc Martinot ^{2, 162} Venkata S. Mattay ^{163, 2} Colm Mcdonald ^{164, 2} Andrew Mcintosh ^{165, 2} Francis J. Mcmahon ² Katie L. Mcmahon ^{166, 2} Patrizia Mecocci ^{167, 2} Ingrid Melle ^{91, 168, 169, 170, 2} Andreas Meyer-Lindenberg ^{171, 2} Sebastian Mohnke ^{172, 2} Grant W. Montgomery ^{173, 76, 2} Derek W. Morris ² Thomas H. Mosley ^{174, 2} Thomas W. Mühleisen ^{55, 56, 2} Bertram Müller-Myhsok ^{175, 2} Michael A. Nalls ^{176, 2} Matthias Nauck ^{177, 2} Thomas E. Nichols ^{178, 2} Wiro J. Niessen ^{179, 14, 2} Markus M. Nöthen ^{180, 2} Lars Nyberg ^{181, 2} Kazutaka Ohi ^{182, 2} Rene L. Olvera ^{183, 2} Roel A. Ophoff ^{184, 2} Massimo Pandolfo ^{124, 2} Tomas Paus ^{185, 186, 2} Zdenka Pausova ^{187, 2} Brenda W. J. H. Penninx ^{173, 2} G. Bruce Pike ^{5, 2} Steven G. Potkin ^{188, 2} Bruce M. Psaty ² Simone Reppermund ^{100, 2} Marcella Rietschel ^{189, 190, 2} Joshua L. Roffman ^{191, 2} Nina Romanczuk-Seiferth ^{172, 2} Jerome I. Rotter ^{192, 2} Mina Ryten ^{80, 193, 2} Ralph L. Sacco ^{194, 2} Perminder S. Sachdev ² Andrew Saykin ^{59, 60, 172, 2} Reinhold Schmidt ^{195, 2} Helena Schmidt ^{196, 2} Peter R. Schofield ^{197, 2} Sigurdur Sigursson ^{5, 2} Andrew Simmons ² Andrew Singleton ^{176, 2} Sanjay M. Sisodiya ² Colin Smith ² Jordan W. Smoller ^{198, 2} Hilkka Soininen ^{199, 2} Vidar M. Steen ^{21, 2} David J. Stott ² Jessika E. Sussmann ^{18, 2} Anbupalam Thalamuthu ^{200, 2} Arthur W. Toga ^{41, 2} Bryan J. Traynor ^{201, 2} Juan Troncoso ² Magda Tsolaki ^{202, 2} Christophe Tzourio ^{203, 204, 2} Andre G. Uitterlinden ² Maria C. Valdés Hernández ² Marcel van Der Brug ^{205, 2} Aad van Der Lugt ^{206, 2} Nic J. A. van Der Wee ^{207, 2} Neeltje E. M. van Haren ^{11, 2} Dennis van ’t Ent ² Marie-Jose van Tol ^{208, 2} Badri N. Vardarajan ² Bruno Vellas ^{209, 2} Dick J. Veltman ^{58, 2} Henry Völzke ^{210, 2} Henrik Walter ^{211, 172, 2} Joanna M. Wardlaw ² Thomas H. Wassink ^{212, 2} Michael E. Weale ^{213, 2} Daneil R Weinberger ² Michael W. Weiner ² Wei Wen ² Eric Westman ^{214, 2} Tonya White ² Tien Y. Wong ² Clinton B. Wright ^{215, 2} Ronald H. Zielke ^{5, 2} Alan B. Zonderman ^{89, 2} Nicholas G. Martin ² Cornelia M. van Duijn ^{14, 2} Margaret J. Wright ^{216, 2} W. T. Longstreth ^{5, 2} Gunter Schumann ² Hans J. Grabe ^{217, 2} Barbara Franke ^{218, 2} Lenore J. Launer ^{5, 2} Sarah E. Medland ^{76, 2} Sudha Seshadri ² Paul M. Thompson ^{219, 2} M. Arfan Ikram ²

1 David Geffen School of Medicine [Los Angeles]

2 Metacohorts Consortium

3 Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique

4 INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France

5 sans affiliation

6 QIMR Berghofer Medical Research Institute

7 University of Washington [Seattle]

8 Department of Psychiatry

9 Department of Human Genetics

10 Institute of Psychiatry, Psychology & Neuroscience, King's College London

11 University Medical Center [Utrecht]

12 Department of Neurology and Neurosurgery [Montreal]

13 Molecular and Cellular Therapeutics

14 Erasmus MC - Erasmus University Medical Center [Rotterdam]

15 Sahlgrenska University Hospital [Gothenburg]

16 Department of Biomedical Engineering

17 Rush University Medical Center [Chicago]

18 University of Edinburgh

19 LASU - Lagos State University

20 APHM - Assistance Publique - Hôpitaux de Marseille

21 UiO - University of Oslo

22 Department of medical sciences

23 John P. Hussman Institute for Human Genomics

24 BUSM - Boston University School of Medicine

25 BU - Boston University [Boston]

26 University of Toronto

27 Genetics

28 Radboud University Medical Center [Nijmegen]

29 Donders Institute for Brain, Cognition and Behaviour

30 UCDavis-Neuro - Neurology Department, University of California, Davis

31 Douglas Mental Health University Institute

32 Université Lille Nord de France (COMUE)

33 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167

34 GIN - Groupe d'imagerie neurofonctionnelle

IMN - Institut des Maladies Neurodégénératives [Bordeaux], CEA - Commissariat à l'énergie atomique et aux énergies alternatives

35 MetaGenoPolis

36 Haukeland University Hospital

37 Ames Laboratory [Ames, USA]

38 Johns Hopkins University School of Medicine [Baltimore]

39 Language and Genetics Department [Nijmegen]

40 IMPRS - International Max Planck Research School for Language Sciences

41 LONI - Laboratory of Neuro Imaging [Los Angeles]

42 Department of Mathematics [UCLA]

43 Georgia Institute of Technology [Atlanta]

44 Medizinische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Germany

45 Greifswald University Hospital

46 BNU - Beijing Normal University

47 AAU - Aalborg University [Denmark]

48 UCL Institute of Neurology and Epilepsy Society

49 Department of Medicine

50 Service d'Endocrinologie [CHRU Nancy]

51 Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen 37075, Germany

52 Medstar Research Institute

53 Clinical And Experimental Epilepsy

54 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia

55 Department of Genomics, Life and Brain Center

56 Institute of Human Genetics

57 Department of Biomedicine and the Centre for Integrative Sequencing

58 Department of Psychiatry

59 Indiana University School of Medicine

60 Indiana Alzheimer Disease Center

61 Institute of Food & Health, University College Dublin,

62 Department of Neurology

63 Statistical Genetics Group

64 Respiratory Epidemiology and Public Health

65 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]

66 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]

67 Department of Neurology [Austria]

68 IPCM - Institut Parisien de Chimie Moléculaire

69 Max Planck Institute of Psychiatry

70 INSERM, Neuroepidemiology U708, Bordeaux, France

71 Department of Neurosciences [San Diego]

72 Department of Cognitive Sciences [San Diego]

73 Wuhan University [China]

74 Plymouth University

75 Dpt of Psychiatry [New Haven]

76 Queensland Institute of Medical Research

77 School of Psychology, University of Queensland, Brisbane 4072, Australia

78 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia

79 CNRS - UMR3571 - Gènes, Synapses et Cognition

80 Reta Lila Weston Institute and Department of Molecular Neuroscience

81 Department of Genetics

82 Depts of Radiology

83 University of Twente [Netherlands]

84 Department of Psychiatry and Human Behavior [Irvine]

85 RCMG Ghent

86 EDC (UMR_7216) - Centre épigénétique et destin cellulaire

87 Department of Psychology [Oslo]

88 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen

89 NIH - National Institutes of Health [Bethesda]

90 Biospective [Montréal]

91 KG Jebsen Centre for Psychosis Research

92 Department of Genetics

93 Department of Psychiatry and National Ageing Research Institute

94 Université de Lille

95 Department of Clinical Genetics

96 Department of Experimental Physics

97 Texas Biomedical Research Institute [San Antonio, TX]

98 UTHealth - The University of Texas Health Science Center at Houston

99 849 Department of Human Genetics

100 Centre for Healthy Brain Ageing

101 Dementia Collaborative Research Centre

102 Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands

103 Department of Psychiatry [Boston]

104 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia

105 Department of Psychiatry

106 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]

107 The Mind Research Network

108 Human Genetics Branch

109 Division of Molecular and Cellular Therapeutics

110 NPU - Northwestern Polytechnical University [Xi'an]

111 INM-1 - Institute of Neuroscience and Medicine

112 Division of Medical Genetics

113 Cell Biology and Gene Expression Section

114 Department of Psychiatry

115 Neuropsychiatric Genetics Research Group

116 Bijvoet Center of Biomolecular Research [Utrecht]

117 York Structural Biology Laboratory, Department of Chemistry

118 HMS - Harvard Medical School [Boston]

119 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA

120 Program in Translational NeuroPsychiatric Genomics,

121 School of Psychology, University of Queensland

122 Epidémiologie et Biostatistique [Bordeaux]

123 Neurology Division, Beaumont Hospital, Dublin 9, Ireland

124 Department of Neurology

125 Laboratory of Neurogenetics

NIH - National Institutes of Health [Bethesda]

126 Department of Genomics

127 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands

128 ISM - Institut des Sciences du Mouvement Etienne Jules Marey

129 EHESS - École des hautes études en sciences sociales

130 Department of Radiology

131 Robertson Centre for Biostatistics, University of Glasgow

132 Human Genetics Center

133 Department of Medical and Molecular Genetics

134 RPI - Rensselaer Polytechnic Institute

135 Department of Physics, Okayama University

136 University of New Haven [Connecticut]

137 Athinoula A. Martinos Center for Biomedical Imaging

138 Public Health Genomics Unit

139 Department of Mathematics, University of Colorado

140 Faculty of Medicine

141 Icelandic Heart Association, Kopavogur, Iceland.

142 UCL, Institute of Neurology [London]

143 University of Science, VNU-HCM

144 Department of Psychiatry

145 Neuronal Plasticity / Mouse Behaviour

146 Interfaculty Institute for Genetics and Functional Genomics

147 Department of Medical Genetics

148 University of Oxford [Oxford]

149 UF - University of Florida [Gainesville]

150 GU - Göteborgs Universitet

151 Department of Medicine, Clinical Pharmacology Unit

152 Brain Centre Rudolf Magnus [Utrecht]

153 School of Psychology, University of Sussex, Brighton BN1 9QH, UK

154 Institute of Cognitive Neuroscience

155 MUL - Medical University of Łódź

156 Department of Neurology

157 Department of Psychiatry

158 School of Biomedical Sciences, Faculty of Biological Sciences

159 UCP - Université de Cergy Pontoise

160 Lymphocyte Cell Biology Unit, Laboratory of Genetics

161 Psychiatry Institute

162 UNH - Unité de Nutrition Humaine

163 Department of Health and Human Services

164 Department of Life Sciences

165 MSI - Mathematical Sciences Institute

166 Centre for Advanced Imaging

167 Institute of Gerontology and Geriatrics

168 Division of Mental Health and Addiction

169 Institute of Clinical Medicine [Oslo]

170 Division of Mental Health and Addiction

171 Medical Faculty [Mannheim]

172 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]

173 Genetic Epidemiology Unit

174 UMMC - University of Mississippi Medical Center

175 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy

176 Laboratory of Neurogenetics

NIH - National Institutes of Health [Bethesda]

177 Institute of Clinical Chemistry and Laboratory Medicine

178 Department of Statistics [Coventry]

179 TU Delft - Delft University of Technology

180 Rheinische Friedrich-Wilhelms-Universität Bonn

181 Department of Health Science, Division of Health and Rehabilitation

182 Department of Psychiatry

183 Department of Medical and Molecular Genetics

184 Department of Psychiatry

185 UON - University of Nottingham, UK

186 MNI - McConnell Brain Imaging Centre

187 Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada

188 Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA

189 Department of Genetic Epidemiology in Psychiatry

190 Department of Psychiatry

191 Department of Psychiatry

192 Cedars-Sinai Medical Center

193 Department of Medical and Molecular Genetics

194 POLIMI - Politecnico di Milano [Milan]

195 University of Applied Sciences [Munich]

196 Dpt of Pharmacology and Personalised Medicine [Maastricht]

197 Genetics of Mental Illness and Brain Function

198 Massachusetts General Hospital [Boston]

199 Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

200 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia

201 National Institute of Aging

202 3rd Department of Neurology

203 BPH - Bordeaux population health

204 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement

205 Genentech, Inc. [San Francisco]

206 Department of Radiology

207 Psychiatry and Leiden Institute for Brain and Cognition

208 Leiden University Medical Center (LUMC)

209 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps

210 Institute for Community Medicine

211 Berlin School of Mind and Brain [Berlin]

212 Department of Psychiatry

213 Centre for Population Health Sciences

214 Department of Neurobiology, Care Sciences and Society

215 University of Pretoria [South Africa]

216 Mizzou - University of Missouri [Columbia]

217 Department of Psychiatry and Psychotherapy

218 Donders Center for Cognitive Neuroimaging

219 USC - University of Southern California

Abstract : The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r g ¼ À 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Document type :

Journal articles

Domain :

Cognitive science / Neuroscience

Complete list of metadata

https://hal.archives-ouvertes.fr/hal-01488337
Contributor : GIN Hal Connect in order to contact the contributor
Submitted on : Monday, March 13, 2017 - 3:31:15 PM
Last modification on : Monday, July 4, 2022 - 10:23:21 AM
Long-term archiving on: : Wednesday, June 14, 2017 - 2:08:17 PM