Novel genetic loci associated with hippocampal volume

Derrek P. Hibar 1, 2 Hieab H. H. Adams 3, 2 Neda Jahanshad 1, 2 Ganesh Chauhan 4, 2 Jason L. Stein 5, 2 Edith Hofer 5, 2 Miguel E. Renteria 6, 2 Joshua C. Bis 7, 2 Alejandro Arias-Vasquez 8, 9, 2 M. Kamran Ikram 2 Sylvane Desrivières 10, 2 Meike W. Vernooij 2 Lucija Abramovic 11, 2 Saud Alhusaini 12, 13, 2 Najaf Amin 14, 2 Micael Andersson 15, 2 Konstantinos Arfanakis 16, 17, 2 Benjamin S. Aribisala 18, 19, 20, 2 Nicola J. Armstrong 21, 2 Lavinia Athanasiu 22, 23, 2 Tomas Axelsson 24, 2 Ashley H. Beecham 25, 2 Alex Beiser 26, 27, 2 Manon Bernard 28, 2 Susan H. Blanton 29, 2 Marc Bohlken 11, 2 Marco Boks 11, 2 Janita Bralten 30, 31, 32, 2 Adam M. Brickman 5, 2 Owen Carmichael 33, 2 M. Mallar Chakravarty 34, 2 Qiang Chen 5, 2 Christopher Ching 5, 2 Vincent Chouraki 35, 2 Gabriel Cuellar-Partida 6, 2 Fabrice Crivello 36, 2 Anouk Den Braber 5, 2 Nhat Trung Doan 37, 2 Stefan Ehrlich 38, 2 Sudheer Giddaluru 39, 40, 2 Aaron L. Goldman 41, 2 Rebecca F. Gottesman 42, 2 Oliver Grimm 5, 2 Michael E. Griswold 5, 2 Tulio Guadalupe 43, 44, 2 Boris A. Gutman 45, 46, 2 Johanna Hass 47, 2 Unn K. Haukvik 22, 2 David Hoehn 5, 2 Avram J. Ho 48, 2 Martine Hoogman 5, 2 Deborah Janowitz 49, 2 Tianye Jia 50, 2 Kjetil N. Jørgensen 51, 2 Nazanin Karbalai 5, 2 Dalia Kasperaviciute 52, 53, 2 Sungeun Kim 2 Marieke Klein 54, 2 Bernd Kraemer 55, 2 Phil H. Lee 5, 2 David C. Liewald 56, 2 Lorna M. Lopez 2 Michelle Luciano 57, 2 Christine Macare 10, 2 André F. Marquand 2 Mar Matarin 58, 2 Karen A. Mather 59, 2 Manuel Mattheisen 60, 61, 62, 2 David Mckay 2 Yuri Milaneschi 63, 2 Susana Muñoz Maniega 2 Kwangsik Nho 64, 65, 66, 2 Allison C. Nugent 67, 2 Paul Nyquist 68, 2 Loes M. Olde Loohuis 2 Jaap Oosterlaan 2 Martina Papmeyer 2 Lukas Pirpamer 2 Benno Pütz 69, 2 Adaikalavan Ramasamy 70, 2 Jennifer S. Richards 2 Shannon L. Risacher 64, 66, 2 Robert Roiz-Santiañez 71, 2 Nanda Rommelse 72, 73, 2 Stefan Ropele 74, 2 Emma Rose 75, 2 Natalie A. Royle 2 Tatjana Rundek 2 Philipp G. Sämann 76, 2 Arvin Saremi 2 Claudia L. Satizabal 77, 2 Lianne Schmaal 63, 2 Andrew Schork 78, 79, 2 Li Shen 80, 2 Jean Shin 2 Elena Shumskaya 5, 2 Albert Smith 81, 2 Emma Sprooten 82, 2 Lachlan T. Strike 83, 84, 85, 2 Alexander Teumer 2 Diana Tordesillas-Gutierrez 2 Robert Toro 86, 2 Daniah Trabzuni 87, 88, 2 Stella Trompet 2 Dhananjay Vaidya 2 Jeroen Van Der Grond 89, 2 Sven Van Der Lee 2 Dennis Van Der Meer 90, 2 Marjolein M. J. Van Donkelaar 30, 32, 2 Kristel R. Van Eijk 91, 2 Theo G. M. Van Erp 92, 2 Daan Van Rooij 93, 2 Esther Walton 94, 2 Lars Westlye 22, 95, 2 Christophe Whelan 1, 2 Beverly G. Windham 96, 2 Anderson M. Winkler 2 Katharina Wittfeld 49, 97, 2 Girma Woldehawariat 98, 2 Christiane Wolf 2 Thomas Wolfers 5, 2 Lisa R. Yanek 2 Jingyun Yang 2 Alex Zijdenbos 99, 2 Marcel Zwiers 32, 2 Ingrid Agartz 100, 2 Laura Almasy 101, 2 David Ames 102, 2 Philippe Amouyel 103, 2 Ole A Andreassen 2 Sampath Arepalli 104, 2 Amelia A. Assareh 2 Sandra Barral 2 Mark Bastin 105, 2 Diane M. Becker 2 James T. Becker 2 David A. Bennett 106, 2 John Blangero 107, 108, 2 Hans Van Bokhoven 109, 2 Dorret I. Boomsma 2 Henry Brodaty 110, 111, 2 Rachel M. Brouwer 2 Han G. Brunner 2 Randy L. Buckner 112, 2 Jan K. Buitelaar 113, 2 Kazima B. Bulayeva 114, 2 Wiepke Cahn 115, 2 Vince D. Calhoun 116, 117, 2 Dara M. Cannon 118, 2 Gianpiero L. Cavalleri 119, 2 Ching-Yu Cheng 120, 2 Sven Cichon 60, 61, 121, 122, 2 Mark Cookson 123, 2 Aiden Corvin 124, 125, 2 Benedicto Crespo-Facorro 71, 2 Joanne E. Curran 2 Michael Czisch 126, 2 Anders M. Dale 2 Gareth E. Davies 127, 2 Anton J. M. De Craen 2 Eco J. C. De Geus 2 Philip L. De Jager 128, 129, 130, 2 Greig I. De Zubicaray 131, 2 Ian Deary 2 Stéphanie Debette 132, 2 Charles Decarli 2 Norman Delanty 13, 133, 2 Chantal Depondt 134, 2 Anita Destefano 27, 2 Allissa Dillman 135, 2 Srdjan Djurovic 2 Gary Donohoe 124, 118, 2 Wayne C. Drevets 118, 2 Ravi Duggirala 107, 2 Thomas Dyer 107, 108, 2 Christian Enzinger 2 Susanne Erk 136, 2 Thomas Espeseth 23, 95, 2 Iryna O. Fedko 137, 2 Guillén Fernández 138, 2 Luigi Ferrucci 5, 2 Simon Fisher 139, 2 Debra A. Fleischman 140, 141, 17, 2 Ian Ford 142, 2 Myriam Fornage 143, 144, 2 Tatiana M. Foroud 145, 2 Peter Fox 146, 2 Clyde Francks 32, 43, 2 Masaki Fukunaga 147, 2 J. Raphael Gibbs 148, 2 David C. Glahn 82, 2 Randy L. Gollub 149, 2 Harald H. H. Göring 150, 2 Robert Green 151, 2 Oliver Gruber 152, 2 Vilmundur Gudnason 153, 154, 2 Sebastian Guelfi 87, 2 Asta K. Håberg 2 Narelle K. Hansell 57, 2 John Hardy 155, 2 Catharina A. Hartman 57, 2 Ryota Hashimoto 2 Katrin Hegenscheid 156, 2 Andreas Heinz 2 Stephanie Le Hellard 39, 40, 2 Dena G. Hernandez 2 Dirk J. Heslenfeld 156, 2 Beng-Choon Ho 157, 2 Pieter J. Hoekstra 158, 2 Wolfgang Hoffmann 2 Albert Hofman 2 Florian Holsboer 159, 2 Georg Homuth 160, 2 Norbert Hosten 156, 2 Jouke-Jan Hottenga 2 Matthew Huentelman 161, 2 Hilleke E. Hulshoff Pol 2 Masashi Ikeda 2 Clifford R. Jack Jr 2 Mark Jenkinson 162, 2 Robert Johnson 163, 164, 2 Erik G. Jönsson 165, 2 J. Wouter Jukema 2 René S. Kahn 166, 2 Ryota Kanai 167, 168, 2 Iwona Kloszewska 169, 2 David S. Knopman 170, 2 Peter Kochunov 171, 2 John B. Kwok 172, 2 Stephen M. Lawrie 173, 2 Hervé Lemaître 174, 2 Xinmin Liu 2 Dan L. Longo 175, 2 Oscar L. Lopez 2 Simon Lovestone 176, 2 Oliver Martinez 2 Jean-Luc Martinot 177, 2 Venkata S. Mattay 178, 2 Colm Mcdonald 179, 2 Andrew Mcintosh 180, 2 Francis J. Mcmahon 2 Katie L. Mcmahon 181, 2 Patrizia Mecocci 182, 2 Ingrid Melle 100, 183, 184, 185, 2 Andreas Meyer-Lindenberg 186, 2 Sebastian Mohnke 187, 2 Grant W. Montgomery 188, 189, 2 Derek W. Morris 2 Thomas H. Mosley 190, 191, 2 Thomas W. Mühleisen 60, 61, 2 Bertram Müller-Myhsok 192, 2 Michael A. Nalls 193, 2 Matthias Nauck 194, 2 Thomas E. Nichols 195, 2 Wiro J. Niessen 196, 197, 2 Markus M. Nöthen 198, 2 Lars Nyberg 199, 2 Kazutaka Ohi 200, 2 Rene L. Olvera 201, 2 Roel A. Ophoff 202, 2 Massimo Pandolfo 134, 2 Tomas Paus 203, 204, 2 Zdenka Pausova 205, 2 Brenda W. J. H. Penninx 188, 2 G. Bruce Pike 5, 2 Steven G. Potkin 206, 2 Bruce M. Psaty 2 Simone Reppermund 110, 2 Marcella Rietschel 207, 208, 2 Joshua L. Roffman 209, 2 Nina Romanczuk-Seiferth 187, 2 Jerome I. Rotter 210, 2 Mina Ryten 87, 211, 2 Ralph L. Sacco 212, 2 Perminder S. Sachdev 2 Andrew Saykin 64, 66, 187, 2 Reinhold Schmidt 213, 2 Helena Schmidt 214, 2 Peter R. Schofield 215, 2 Sigurdur Sigursson 5, 2 Andrew Simmons 2 Andrew Singleton 193, 2 Sanjay M. Sisodiya 2 Colin Smith 2 Jordan W. Smoller 216, 2 Hilkka Soininen 217, 2 Vidar M. Steen 39, 2 David J. Stott 2 Jessika E. Sussmann 173, 2 Anbupalam Thalamuthu 218, 2 Arthur W. Toga 45, 2 Bryan J. Traynor 219, 2 Juan Troncoso 2 Magda Tsolaki 220, 2 Christophe Tzourio 221, 222, 2 Andre G. Uitterlinden 2 Maria C. Valdés Hernández 2 Marcel Van Der Brug 223, 2 Aad Van Der Lugt 224, 2 Nic J. A. Van Der Wee 225, 2 Neeltje E. M. Van Haren 11, 2 Dennis Van ’t Ent 2 Marie-Jose Van Tol 226, 2 Badri N. Vardarajan 2 Bruno Vellas 227, 2 Dick J. Veltman 63, 2 Henry Völzke 228, 2 Henrik Walter 229, 230, 2 Joanna M. Wardlaw 2 Thomas H. Wassink 231, 2 Michael E. Weale 232, 2 Daneil R Weinberger 2 Michael W. Weiner 2 Wei Wen 2 Eric Westman 233, 2 Tonya White 2 Tien Y. Wong 2 Clinton B. Wright 234, 2 Ronald H. Zielke 5, 2 Alan B. Zonderman 235, 2 Nicholas G. Martin 2 Cornelia M. Van Duijn 236, 2 Margaret J. Wright 237, 2 W. T. Longstreth 5, 2 Gunter Schumann 2 Hans J. Grabe 238, 2 Barbara Franke 239, 2 Lenore J. Launer 5, 2 Sarah E. Medland 83, 2 Sudha Seshadri 2 Paul M. Thompson 240, 2 M. Arfan Ikram 2
1 Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California, Los Angeles, California, USA
2 Metacohorts Consortium
3 Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
4 INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France
5 sans affiliation
6 QIMR Berghofer Medical Research Institute
7 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
8 Department of Psychiatry
9 Department of Human Genetics
10 MRC- SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK
11 Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
12 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Canada
13 Molecular and Cellular Therapeutics, The Royal College of Surgeons, Dublin 2, Ireland
14 Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
15 Sahlgrenska University Hospital
16 Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA
17 Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA
18 Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
19 Department of Computer Science, Lagos State University, Lagos, Nigeria
20 Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH4 2XU, UK
21 APHM - Assistance Publique - Hôpitaux de Marseille
22 NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo N-0316, Norway
23 NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0424, Norway
24 Department of medical sciences
25 John P. Hussman Institute for Human Genomics
26 Department of Neurology, Boston University School of Medicine, Framingham Heart Study, Boston, MA
27 Department of Biostatistics, Boston University School of Public Health
28 CRMBM - Centre de résonance magnétique biologique et médicale
29 Genetics
30 Department of Human Genetics, Radboud university medical center, Nijmegen 6500 HB, The Netherlands
31 Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen 6500 HB, The Netherlands
32 Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6500 GL, The Netherlands
33 UCDavis-Neuro - Neurology Department, University of California, Davis
34 Douglas Mental Health University Institute
35 Université Lille Nord de France
36 GIN - IMN UMR 5293 CNRS CEA Université de Bordeaux
IMN - Institut des Maladies Neurodégénératives [Bordeaux]
37 INRS-IAF - Institut Armand Frappier
38 MetaGenoPolis
39 NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway
40 Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen 5021, Norway
41 Ames Laboratory (Ames, USA)
42 Department of Neurology, Johns Hopkins University School of Medicine
43 Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands
44 International Max Planck Research School for Language Sciences, Nijmegen 6525 XD, The Netherlands
45 LONI - Laboratory of Neuro Imaging [Los Angeles]
46 Department of Mathematics [UCLA]
47 GATECH - Georgia Institute of Technology
48 Medizinische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Germany
49 Department of Psychiatry, University Medicine Greifswald, Greifswald 17489, Germany
50 Beijing Normal University
51 Aalborg University [Denmark]
52 UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, London WC1N 3BG, UK
53 Department of Medicine, Imperial College London, London W12 0NN, UK
54 Service d ' Endocrinologie
55 Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen 37075, Germany
56 Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK
57 Medstar Research Institute
58 Clinical And Experimental Epilepsy
59 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
60 Department of Genomics, Life and Brain Center
61 Institute of Human Genetics
62 Department of Biomedicine and the Centre for Integrative Sequencing
63 Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 HL, The Netherlands
64 Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
65 Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
66 Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
67 Institute of Food & Health, University College Dublin,
68 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
69 Statistical Genetics Group
70 Respiratory Epidemiology and Public Health
71 Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid 28029, Spain
72 Karakter Child and Adolescent Psychiatry University Center Nijmegen
73 Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior
74 Department of Neurology [Austria]
75 IPCM - Institut Parisien de Chimie Moléculaire
76 Max Planck Institute of Psychiatry, Munich 80804, Germany
77 INSERM, Neuroepidemiology U708, Bordeaux, France
78 Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, California 92093, USA
79 Department of Cognitive Sciences, University of California, San Diego, California 92161, USA
80 Wuhan University [China]
81 Plymouth University
82 Dpt of Psychiatry [New Haven]
83 Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
84 School of Psychology, University of Queensland, Brisbane 4072, Australia
85 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia
86 Gènes, Synapses et Cognition
87 Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK
88 Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
89 Depts of Radiology
90 University of Twente [Netherlands]
91 University Medical Center Utrecht
92 Department of Psychiatry and Human Behavior [Irvine]
93 RCMG Ghent
94 EDC - Centre épigénétique et destin cellulaire
95 Department of Psychology, University of Oslo, Oslo 0373, Norway
96 Division of geriatrics, gerontology
97 German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald 17487, Germany
98 Human Genetics Branch and Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland 20892, USA
99 Biospective, Inc., Montreal, Quebec, Canada
100 KG Jebsen Centre for Psychosis Research
101 Department of Genetics
102 Department of Psychiatry and National Ageing Research Institute
103 Université de Lille
104 Department of Clinical Genetics
105 University of Edinburgh
106 Department of Experimental Physics
107 Texas Biomedical Research Institute, San Antonio, Texas 78245, USA
108 University of Texas Health Science Center, San Antonio, Texas 78229, USA
109 849 Department of Human Genetics
110 Centre for Healthy Brain Ageing
111 Dementia Collaborative Research Centre
112 Department of Psychiatry [Boston]
113 Donders Institute for Brain, Cognition and Behaviour
114 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
115 Department of Psychiatry
116 Department of ECE, University of New Mexico, Albuquerque, New Mexico 87131, USA
117 The Mind Research Network & LBERI, Albuquerque, New Mexico 87106, USA
118 Human Genetics Branch
119 Division of Molecular and Cellular Therapeutics
120 NPU - Northwestern Polytechnical University [Xi'an]
121 INM-1 - Institute of Neuroscience and Medicine
122 Division of Medical Genetics
123 Cell Biology and Gene Expression Section
124 Department of Psychiatry
125 Neuropsychiatric Genetics Research Group
126 Bijvoet Center of Biomolecular Research
127 York Structural Biology Laboratory, Department of Chemistry
128 Harvard Medical School, Boston, Massachusetts, USA
129 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
130 Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
131 School of Psychology, University of Queensland
132 Epidémiologie et Biostatistique [Bordeaux]
133 Neurology Division, Beaumont Hospital, Dublin 9, Ireland
134 Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels 1070, Belgium
135 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
136 Department of Genomics
137 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands
138 ISM - Institut des Sciences du Mouvement Etienne Jules Marey
139 EHESS - École des hautes études en sciences sociales
140 Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA
141 Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
142 Robertson Centre for Biostatistics, University of Glasgow
143 Human Genetics Center, School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
144 Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
145 Department of Medical and Molecular Genetics
146 RPI - Rensselaer Polytechnic Institute
147 Department of Physics, Okayama University
148 University of New Haven [Connecticut]
149 Athinoula A. Martinos Center for Biomedical Imaging
150 Public Health Genomics Unit
151 Department of Mathematics, University of Colorado
152 SARDES - System architecture for reflective distributed computing environments
Inria Grenoble - Rhône-Alpes, LIG - Laboratoire d'Informatique de Grenoble
153 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
154 Icelandic Heart Association, Kopavogur, Iceland.
155 laboratoire de Science et Génie Alimentaires
156 Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald 17475, Germany
157 University of Science, VNU-HCM
158 Department of Psychiatry
159 Neuronal Plasticity / Mouse Behaviour
160 Interfaculty Institute for Genetics and Functional Genomics
161 Department of Medical Genetics
162 University of Oxford [Oxford]
163 University of Florida [Gainesville]
164 Göteborg Universitet (SWEDEN)
165 Department of Medicine, Clinical Pharmacology Unit
166 Brain Centre Rudolf Magnus [Utrecht]
167 School of Psychology, University of Sussex, Brighton BN1 9QH, UK
168 nstitute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK
169 Medical University of Lodz, Lodz 90-419, Poland
170 Department of Neurology
171 Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21201, USA
172 School of Biomedical Sciences, Faculty of Biological Sciences
173 Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK
174 Université de Cergy Pontoise
175 Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
176 Psychiatry Institute
177 UNH - Unité de Nutrition Humaine
178 Department of Health and Human Services
179 Department of Life Sciences
180 MSI - Mathematical Sciences Institute
181 Centre for Advanced Imaging
182 Institute of Gerontology and Geriatrics
183 Division of Mental Health and Addiction
184 Institute of Clinical Medicine
185 Division of Mental Health and Addiction
186 Medical Faculty Mannheim
187 Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany
188 Genetic Epidemiology Unit
189 Queensland Institute of Medical Research
190 Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, USA
191 Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA
192 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
193 Laboratory of Neurogenetics
194 Institute of Clinical Chemistry and Laboratory Medicine
195 Department of Statistics [Coventry]
196 Delft University of Technology
197 Erasmus University Medical Centre Rotterdam [Rotterdam]
198 Bonn Universität [Bonn]
199 Department of Health Science, Division of Health and Rehabilitation
200 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
201 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
202 Department of Psychiatry
203 UON - University of Nottingham, UK
204 MNI - McConnell Brain Imaging Centre
205 Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada
206 Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA
207 Department of Genetic Epidemiology in Psychiatry
208 Department of Psychiatry
209 Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
210 Medical Genetics Institute, Cedars-Sinai Medical Center
211 Department of Medical and Molecular Genetics, King’s College London, London SE1 9RT, UK
212 Politecnico di Milano [Milan]
213 University of Applied Sciences [Munich]
214 Dpt of Pharmacology and Personalised Medicine [Maastricht]
215 Genetics of Mental Illness and Brain Function
216 Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, USA
217 Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
218 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia
219 National Institute of Aging
220 3rd Department of Neurology
221 Bordeaux population Health [Bordeaux]
222 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement
223 Genentech, South San Francisco, California 94080, USA
224 Department of Radiology
225 Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
226 LUMC
227 Epidémiologie et anlyses en santé publique: risques, maladies chroniques et handicaps
228 Institute for Community Medicine
229 Berlin School of Mind and Brain [Berlin]
230 Charite-Universitatsmedizin Berlin [Berlin]
231 Department of Psychiatry
232 Centre for Population Health Sciences
233 Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm SE-141 83, Sweden
234 University of Pretoria [South Africa]
235 Behavioral Epidemiology Section, National Institute on Aging Intramural Research Program, Baltimore, Maryland 20892, USA
236 Erasmus Medical Center
237 University of Missouri-Columbia
238 Department of Psychiatry and Psychotherapy
239 Donders Center for Cognitive Neuroimaging
240 Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA
Abstract : The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r g ¼ À 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Type de document :
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Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. 〈10.1038/ncomms13624〉
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https://hal.archives-ouvertes.fr/hal-01488337
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Derrek P. Hibar, Hieab H. H. Adams, Neda Jahanshad, Ganesh Chauhan, Jason L. Stein, et al.. Novel genetic loci associated with hippocampal volume. Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. 〈10.1038/ncomms13624〉. 〈hal-01488337〉

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