Is It Time to Include CT “Reverse Halo Sign” and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients ?

Denis Caillot (1, 2, 3) , Stéphane Valot (4) , Ingrid Lafon (1) , Louise Basmaciyan (5, 4) , Marie Lorraine Chretien (1, 2, 3) , Marc Sautour (4, 5) , Laurence Million (6, 7) , Caroline Legouge (1, 2, 3) , Alexandre Payssot (1) , Frédéric Dalle (4, 5)

1 Service d'Hématologie Clinique (CHU de Dijon)
2 LNC - Lipides - Nutrition - Cancer (U866)
3 LabEx LipSTIC - Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer
4 Laboratoire de parasitologie mycologie (CHU de Dijon)
5 VAlMiS - Vin Aliment Microbiologie et Stress
6 LCE - Laboratoire Chrono-environnement (UMR 6249)
7 Service de parasitologie et mycologie [CHRU de Besançon]

In 23 leukemia patients with proven (n = 17) or possible (n = 6) pulmonary mucormycosis (PM), the presence of reversed halo sign on computed tomography was strongly associated with the positivity of quantitative polymerase chain reaction assays targeting Mucorales in the serum, confirming the value of these two tools for the diagnosis of PM in this setting.

Mots clés: Early diagnosis; Leukemia; Pulmonary mucormycosis; Quantitative polymerase chain reaction; Reversed halo sign

Domaines: Mycologie

Denis Caillot, Stéphane Valot, Ingrid Lafon, Louise Basmaciyan, Marie Lorraine Chretien, et al.. Is It Time to Include CT “Reverse Halo Sign” and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients ?. Open Forum Infectious Diseases, 2016, 3 (4), ⟨10.1093/ofid/ofw190⟩. ⟨hal-01484030⟩