Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
Résumé
In tissue engineering, it is still rare today to see clinically transferable strategies for
tissue-engineered graft production that conclusively offer better tissue regeneration than the
already existing technologies, decreased recovery times, and less risk of complications. Here a
novel tissue-engineering concept is presented for the production of living bone implants com
bining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone
cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for
the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy
presented here shows a complete closure of a defect in nude mice calvaria after only 31 days.
As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the
therapeutic efficacy of living bone implants.