Epoxide hydrolase and its application in organic synthesis

Alain Archelas (1) , Gilles Iacazio (1) , Michael Kotik (2)

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 Institute of Microbiology

Organic chemists have become interested in enzymes as catalysts due to their high efficiencies and specificities. Moreover, recent progress in molecular biology and enzyme-related research areas enabled and simplified the production and purification of recombinant enzymes in large quantities and their engineering towards tailor-made biocatalysts using straightforward mutagenesis and screening techniques. This is also true for epoxide hydrolases (EHs), as evidenced by the many published research papers about the synthetic applications of naturally occurring or engineered EHs.

Domaines: Chimie

Alain Archelas, Gilles Iacazio, Michael Kotik. Epoxide hydrolase and its application in organic synthesis. Green Biocatalysis, 2016, 978-1-118-82229-6. ⟨hal-01477037⟩