Swinger RNA self-hybridization and mitochondrial non-canonical swinger ă transcription, transcription systematically exchanging nucleotides

Herve Seligmann (1)

1 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes

Stem-loop hairpins punctuate mitochondrial post-transcriptional ă processing. Regulation of mitochondrial swinger transcription, ă transcription producing RNAs matching the mitogenome only assuming ă systematic exchanges between nucleotides (23 bijective transformations ă along 9 symmetric exchanges X < > Y, e.g. A < > G, and 14 asymmetric ă exchanges X > Y > Z > X, e.g. A > G > C > A) remains unknown. Does ă swinger RNA self-hybridization regulate swinger, as regular, ă transcription? Groups of 8 swinger transformations share canonical ă self-hybridization properties within each group, group 0 includes ă identity (regular) transcription. The human mitogenome has more ă stem-loop hairpins than randomized sequences for all groups. Group 2 ă transformations reveal complementarity of the light strand replication ă origin (OL) loop and a neighboring tRNA gene, detecting the longtime ă presumed OL/tRNA homology. Non-canonical G=U pairings in hairpins ă increases with swinger RNA detection. These results confirm biological ă relevancy of swinger-transformed DNA/RNA, independently of, and in ă combination with, previously detected swinger DNA/RNA and swinger ă peptides. Swinger-transformed mitogenomes include unsuspected ă multilayered information. (c) 2016 Elsevier Ltd. All rights reserved.

Domaines: Maladies infectieuses

Herve Seligmann. Swinger RNA self-hybridization and mitochondrial non-canonical swinger ă transcription, transcription systematically exchanging nucleotides. Journal of Theoretical Biology, 2016, 399, pp.84-91. ⟨10.1016/j.jtbi.2016.04.007⟩. ⟨hal-01466867⟩