Introduction of disulfide bridges within silica nanoparticles to control their intra-cellular degradation

Sandrine Quignard (1) , Sylvie Masse (1) , Guillaume Laurent (2, 1) , Thibaud Coradin (1)

1 LCMCP-MATBIO - Matériaux et Biologie
2 SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé

Incorporation of disulfide bridges in the core structure of silica nanoparticles modifies their intracellular fate within dermal fibroblasts, especially influencing their degradation pathway.

Domaines: Matériaux; Chimie thérapeutique

Sandrine Quignard, Sylvie Masse, Guillaume Laurent, Thibaud Coradin. Introduction of disulfide bridges within silica nanoparticles to control their intra-cellular degradation. Chemical Communications, 2013, 49 (33), pp.3410-3412. ⟨10.1039/c3cc41062e⟩. ⟨hal-01461411⟩