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VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.

Abstract : The type VI secretion system (T6SS) is a macromolecular machine that delivers protein effectors into both prokaryotic and eukaryotic cells, therefore participating in interbacterial competition and virulence. The T6SS is functionally and structurally similar to the contractile bacteriophage cell puncturing device: the contraction of a sheath-like structure is believed to propel an inner tube terminated by a spike towards target cells, allowing the delivery of effectors. In this review, we summarize recent advances in the identification and characterization of T6SS effector proteins, highlighting the broad repertoire of enzymatic activities, and discuss recent findings relating to the secretion mechanisms.
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https://hal.archives-ouvertes.fr/hal-01458195
Contributor : Isabelle Marinari Connect in order to contact the contributor
Submitted on : Monday, February 6, 2017 - 5:46:45 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:43 PM

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Eric Durand, Christian Cambillau, E. Cascales, Laure Journet. VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.. Trends Microbiol., 2014, 22 (9), pp.498--507. ⟨10.1016/j.tim.2014.06.004⟩. ⟨hal-01458195⟩

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