Orosomucoid, a new biomarker in the association between obesity and periodontitis.

Hélène Rangé (1, 2) , Christine Poitou (3, 4) , Adrien Boillot (5) , Cécile Ciangura (4) , Sandrine Katsahian (6, 7) , Jean-Marc Lacorte (3) , Sébastien Czernichow (8, 9) , Olivier Meilhac (10) , Philippe Bouchard (11) , Catherine Chaussain (12, 13)

1 LBPC (U698) - Hémostase, bio-ingénierie et remodelage cardiovasculaires
2 CHU Rothschild [AP-HP]
3 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
4 CHU Pitié-Salpêtrière [AP-HP]
5 CONSTANCES - Cohortes épidémiologiques en population
6 Unité de Biostatistiques
7 Service d’informatique et statistiques
8 UPD5 - Université Paris Descartes - Paris 5
9 HEGP - Hôpital Européen Georges Pompidou [APHP]
10 DéTROI - Diabète athérothrombose et thérapies Réunion Océan Indien
11 CEMEF - Centre de Mise en Forme des Matériaux
12 EA 2496 - Pathologies, Imagerie et Biothérapies oro-faciales
13 Service d'Odontologie [Bretonneau]

Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p<0.04) after adjustment for age, gender and smoking. Our study thus suggests that the severity of periodontitis, in morbidly obese patients, is associated with the increase of orosomucoid levels.

Domaines: Sciences du Vivant [q-bio]

Hélène Rangé, Christine Poitou, Adrien Boillot, Cécile Ciangura, Sandrine Katsahian, et al.. Orosomucoid, a new biomarker in the association between obesity and periodontitis.. PLoS ONE, 2013, 8 (3), pp.e57645. ⟨10.1371/journal.pone.0057645⟩. ⟨hal-01446905⟩