Approximations of the allelic frequency spectrum in general supercritical branching populations

Abstract : We consider a general branching population where the lifetimes of individuals are i.i.d. with arbitrary distribution and where each individual gives birth to new individuals at Poisson times independently from each other. In addition, we suppose that individuals experience mutations at Poissonian rate θ under the infinitely many alleles assumption assuming that types are transmitted from parents to offspring. This mechanism leads to a partition of the population by type, called the allelic partition. The main object of this work is the frequency spectrum A(k, t) which counts the number of families of size k in the population at time t. The process (A(k, t), t ∈ R +) is an example of non-Markovian branching process belonging to the class of general branching processes counted by random characteristics. In this work, we propose methods of approximation to replace the frequency spectrum by simpler quantities. Our main goal is study the asymptotic error made during these approximations through central limit theorems. In a last section, we perform several numerical analysis using this model, in particular to analyze the behavior of one of these approximations with respect to Sabeti's Extended Haplotype Homozygosity.
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https://hal.archives-ouvertes.fr/hal-01445838
Contributor : Benoît Henry <>
Submitted on : Monday, February 12, 2018 - 1:48:13 PM
Last modification on : Thursday, May 3, 2018 - 11:42:35 AM
Long-term archiving on : Sunday, May 13, 2018 - 12:22:08 PM

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Benoît Henry. Approximations of the allelic frequency spectrum in general supercritical branching populations. 2018. ⟨hal-01445838v2⟩

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