How to optimize metabolites concentrations and fluxes in a metabolic pathway? Backgrounds and Basics

Christine Nazaret (1) , Sophie Colombié (2) , Bertrand Beauvoit (2) , Martine Dieuaide-Noubhani (2) , Jean-Pierre Mazat (3) , Yves Gibon (4, 2)

1 IMB - Institut de Mathématiques de Bordeaux
2 BFP - Biologie du fruit et pathologie
3 Physiopathologie mitochondriale
4 1074 Institut de Biologie Végétale Moléculaire : actions communes

The modelling of metabolic pathways is developed here for application to sugar metabolism of tomatoes during fruit expansion. In the now classic calculation of network fluxes, we add concentrations. Under assumptions of steady state and of "minimal effort" as proposed in [1], fluxes and concentrations, respecting constraints of experimental measurements and of thermodynamics, are searched. In order to obtain a well-posed problem, a preliminary mathematical study is in progress.

Domaines: Mathématiques [math]; Botanique

Christine Nazaret, Sophie Colombié, Bertrand Beauvoit, Martine Dieuaide-Noubhani, Jean-Pierre Mazat, et al.. How to optimize metabolites concentrations and fluxes in a metabolic pathway? Backgrounds and Basics. International Study Group for Systems Biology meeting (ISGSB 2016) , Oct 2016, Jena, Germany. . ⟨hal-01445608⟩