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The mechanism of force transmission at bacterial focal adhesion complexes

Abstract : Various rod-shaped bacteria mysteriously glide on surfaces in the absence of appendages such as flagella or pili. In the deltaproteobacterium Myxococcus xanthus, a putative gliding motility machinery (the Agl-Glt complex) localizes to so-called focal adhesion sites (FASs) that form stationary contact points with the underlying surface. Here we show that the Agl-Glt machinery contains an inner-membrane motor complex that moves intracellularly along a right-handed helical path; when the machinery becomes stationary at FASs, the motor complex powers a left-handed rotation of the cell around its long axis. At FASs, force transmission requires cyclic interactions between the molecular motor and the adhesion proteins of the outer membrane via a periplasmic interaction platform, which presumably involves contractile activity of motor components and possible interactions with peptidoglycan. Our results provide a molecular model of bacterial gliding motility.
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Submitted on : Thursday, January 19, 2017 - 1:56:02 PM
Last modification on : Friday, August 5, 2022 - 10:40:00 AM

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Laura M. Faure, Jean-Bernard Fiche, Leon Espinosa, Adrien Ducret, Vivek Anantharaman, et al.. The mechanism of force transmission at bacterial focal adhesion complexes. Nature, Nature Publishing Group, 2016, 539 (7630), pp.530+. ⟨10.1038/nature20121⟩. ⟨hal-01440771⟩

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