Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis

Frederique Pompeo (1, 2) , Elodie Foulquier (1, 2) , Anne Galinier (1, 2)

1 LCB - Laboratoire de chimie bactérienne
2 IMM - Institut de Microbiologie de la Méditerranée

Bacteria possess many kinases that catalyze phosphorylation of proteins on diverse amino acids including arginine, cysteine, histidine, aspartate, serine, threonine, and tyrosine. These protein kinases regulate different physiological processes in response to environmental modifications. For example, in response to nutritional stresses, the Gram-positive bacterium Bacillus subtilis can differentiate into an endospore; the initiation of sporulation is controlled by the master regulator SpoOA, which is activated by phosphorylation. SpoOA phosphorylation is carried out by a multi component phosphorelay system. These phosphorylation events on histidine and aspartate residues are labile, highly dynamic and permit a temporal control of the sporulation initiation decision. More recently, another kind of phosphorylation, more stable yet still dynamic, on serine or threonine residues, was proposed to play a role in spore maintenance and spore revival. Kinases that perform these phosphorylation events mainly belong to the Hanks family and could regulate spore dormancy and spore germination. The aim of this mini review is to focus on the regulation of sporulation in B. subtilis by these serine and threonine phosphorylation events and the kinases catalyzing them.

Mots clés: Ser/Thr protein kinases; Phosphorylation; Regulation; Sporulation; Bacillus subtilis

Domaines: Bactériologie; Biochimie, Biologie Moléculaire; Biologie cellulaire; Génétique; Immunologie; Sciences de l'environnement

Frederique Pompeo, Elodie Foulquier, Anne Galinier. Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis. Frontiers in Microbiology, 2016, 7, ⟨10.3389/fmicb.2016.00568⟩. ⟨hal-01440753⟩