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B-cell non-Hodgkin lymphoma linked to Coxiella burnetii

Abstract : Bacteria can induce human lymphomas, whereas lymphoproliferative disorders have been described in patients with Q fever. We observed a lymphoma in a patient with Q fever that prompted us to investigate the association between the 2 diseases. We screened 1468 consecutive patients of the 2004 to 2014 French National Referral Center for Q fever database. The standardized incidence ratios (SIRs) of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) were calculated comparatively to the 2012 Francim Registry. The presence of Coxiella burnetii was tested using immunofluorescence and fluorescence in situ hybridization using a specific 16S ribosomal RNA probe and genomic DNA probe. Seven patients (0.48%) presented mature B-cell lymphoma consisting of 6 DLBCL and 1 FL. An excess risk of DLBCL and FL was found in Q fever patients compared with the general population (SIR [95% confidence interval], 25.4 [11.4-56.4] and 6.7 [0.9-47.9], respectively). C burnetii was detected in CD68(+) macrophages within both lymphoma and lymphadenitis tissues but localization in CD123(+) plasmacytoid dendritic cells (pDCs) was found only in lymphoma tissues. Q fever patients with persistent focalized infection were found more at risk of lymphoma (hazard ratio, 9.35 [1.10-79.4]). Interleukin-10 (IL10) overproduction (P = .0003) was found in patients developing lymphoma. These results suggest that C burnetii should be added to the list of bacteria that promote human B-cell non-Hodgkin lymphoma, possibly by the infection of pDCs and IL10 overproduction. Screening for early lymphoma diagnosis should be considered in the management of patients with Q fever, especially those with persistent focalized infections.
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https://hal.archives-ouvertes.fr/hal-01440249
Contributor : Chantal Vaffides Connect in order to contact the contributor
Submitted on : Thursday, January 19, 2017 - 10:24:39 AM
Last modification on : Wednesday, November 3, 2021 - 5:21:21 AM

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Clea Melenotte, Matthieu Million, Gilles Audoly, Audrey Gorse, Herve Dutronc, et al.. B-cell non-Hodgkin lymphoma linked to Coxiella burnetii. Blood, American Society of Hematology, 2016, 127 (1), pp.113-121. ⟨10.1182/blood-2015-04-639617⟩. ⟨hal-01440249⟩

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