Lessons from NK Cell Deficiencies in the Mouse

Florence Deauvieau (1) , Aurore Fenis (1) , Francois Dalencon , Nicolas Burdin , Eric Vivier (1) , Yann Kerdiles (1)

1 CIML - Centre d'Immunologie de Marseille - Luminy

Since their discovery in the late 1970s, in vivo studies on mouse natural killer (NK) cell almost entirely relied on the use of depleting antibodies and were associated with significant limitations. More recently, large-scale gene-expression analyses allowed the identification of NKp46 as one of the best markers of NK cells across mammalian species. Since then, NKp46 has been shown to be expressed on other subsets of innate lymphoid cells (ILCs) such as the closely related ILC1 and the mucosa-associated NCR+ ILC3. Based on this marker, several mouse models specifically targeting NKp46-expressing cell have recently been produced. Here, we review recent advances in the generation of models of deficiency in NKp46-expressing cells and their use to address the role of NK cells in immunity, notably on the regulation of adaptive immune responses.

Domaines: Immunologie

Florence Deauvieau, Aurore Fenis, Francois Dalencon, Nicolas Burdin, Eric Vivier, et al.. Lessons from NK Cell Deficiencies in the Mouse. Vivier, E and DiSanto, J and Moretta, A. NATURAL KILLER CELLS, 395, pp.173-190, 2016, Current Topics in Microbiology and Immunology, 978-3-319-23916-3; 978-3-319-23915-6. ⟨10.1007/82_2015_473⟩. ⟨hal-01440235⟩