Skip to Main content Skip to Navigation
Journal articles

Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

Abstract : Severe acute malnutrition (SAM) is associated with inadequate diet, low levels of plasma antioxidants and gut microbiota alterations. The link between gut redox and microbial alterations, however, remains unexplored. By sequencing the gut microbiomes of 79 children of varying nutritional status from three centers in Senegal and Niger, we found a dramatic depletion of obligate anaerobes in malnutrition. This was confirmed in an individual patient data meta-analysis including 107 cases and 77 controls from 5 different African and Asian countries. Specifically, several species of the Bacteroidaceae, Eubacteriaceae, Lachnospiraceae and Ruminococceae families were consistently depleted while Enterococcus faecalis, Escherichia coli and Staphylococcus aureus were consistently enriched. Further analyses on our samples revealed increased fecal redox potential, decreased total bacterial number and dramatic Methanobrevibacter smithii depletion. Indeed, M. smithii was detected in more than half of the controls but in none of the cases. No causality was demonstrated but, based on our results, we propose a unifying theory linking microbiota specificity, lacking anaerobes and archaea, to low antioxidant nutrients, and lower food conversion.
Keywords : Dysbiosis Malnutrition
Complete list of metadatas

Cited literature [50 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01439070
Contributor : Yves Bourne <>
Submitted on : Thursday, May 24, 2018 - 4:19:50 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:16 PM

File

srep26051.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Matthieu Million, Maryam Tidjani Alou, Saber Khelaifia, Dipankar Bachar, Jean-Christophe Lagier, et al.. Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition. Scientific Reports, Nature Publishing Group, 2016, 6 (1), pp.26051. ⟨10.1038/srep26051⟩. ⟨hal-01439070⟩

Share

Metrics

Record views

371

Files downloads

708