Combining both quantum mechanics and Hierarchical Organisation of Spherical Environments for natural products 2D NMR spectra simulation

Sergio Ortiz (1) , Mustapha-Kamel Dali-Yahia (2) , Raphäel Grougnet (1) , Yannick Estevez (3) , Sylvie Michel (1) , Sabrina Boutefnouchet (1) , Grégory Genta-Jouve (1)

1 COMETE - UMR 8638 - Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
2 Université de Tlemcen
3 UMR ECOFOG - Ecologie des forêts de Guyane

Structure elucidation of unknown compounds has been the task of natural products chemists for a long time and their approach seems to be the most efficient when it comes to identification. Very recently, Kokkotou et al. proposed a work-flow based on an integrative approach for new metabolite identification. This approach, including prediction of 2D NMR HSQC spectra, demonstrated the necessity for implementation of new algorithms leading to the prediction of 2D NMR spectra. Herein we present a method based on both quantum mechanics (QM) and Hierarchical Organisation of Spherical Environments (HOSE) of the prediction 2D NMR spectra.

Domaines: Chemo-informatique; Chimie théorique et/ou physique

Sergio Ortiz, Mustapha-Kamel Dali-Yahia, Raphäel Grougnet, Yannick Estevez, Sylvie Michel, et al.. Combining both quantum mechanics and Hierarchical Organisation of Spherical Environments for natural products 2D NMR spectra simulation. 2016. ⟨hal-01416667⟩