Fresh layers of RNA-mediated regulation in Gram-positive bacteria

Philippe Bouloc (1) , Francis Repoila (2)

1 SRRB - Signalisation et Réseaux de Régulations Bactériens
2 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé

Bacterial regulatory RNAs have been defined as diverse classes of cis and trans elements that may intervene at each step of gene expression, from RNA and protein synthesis to degradation. Here, we report on a few examples from Gram-positive bacteria that extend the definition of regulatory RNAs to include 5' and 3' UTRs that also act as cis and trans regulators. New examples unveil the existence of cis and trans acting regulatory RNAs on a single molecule. Also, we highlight data showing that a key RNA chaperone in Enterobacteriaceae, Hfq, does not fulfill the same role in Gram-positive Firmicutes.

Domaines: Sciences du Vivant [q-bio]

Philippe Bouloc, Francis Repoila. Fresh layers of RNA-mediated regulation in Gram-positive bacteria. Current Opinion in Microbiology, 2016, 30, pp.30 - 35. ⟨10.1016/j.mib.2015.12.008⟩. ⟨hal-01412635⟩