Abstract : To employ data analytics effectively and efficiently on manufacturing systems, engineers and data scientists need to collaborate closely to bring their domain knowledge together. In this paper, we introduce a domain-specific modeling approach to integrate a manufacturing system model with advanced analytics, in particular neural networks, to model predictions. Our approach combines a set of meta-models and transformation rules based on the domain knowledge of manufacturing engineers and data scientists. Our approach uses a model of a manufacturing process and its associated data as inputs, and generates a trained neural network model as an output to predict a quantity of interest. This paper presents the domain-specific knowledge that the approach should employ, the formal workflow of the approach, and a milling process use case to illustrate the proposed approach. We also discuss potential extensions of the approach.