pH-responsive relaxometric behaviour of coordination polymer nanoparticles made of a stable macrocyclic gadolinium macrocyclic chelate

Abstract : Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable Gd(III) chelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r1 =16.4 mm(-1)  s(-1) at 10 MHz), but also for a pH responsiveness (Δr1 =108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.
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Submitted on : Tuesday, November 29, 2016 - 5:58:03 PM
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J. Aríñez-Soriano, Albalad J., Carné-Sánchez J., Celia Bonnet, Busqué C. S., et al.. pH-responsive relaxometric behaviour of coordination polymer nanoparticles made of a stable macrocyclic gadolinium macrocyclic chelate. Chemistry - A European Journal, Wiley-VCH Verlag, 2016, 22 (37), pp.13162-13170. ⟨10.1002/chem.201602356⟩. ⟨hal-01405351⟩

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