Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates

Shady Kotb (1) , Joao Piraquive (2) , Franck Lamberton (3) , François Lux (1) , Michael Verset (4) , Vanessa Di Cataldo (2) , Hugues Contamin (4) , Olivier Tillement (1) , Emmanuelle Canet-Soulas (2) , Lucie Sancey (1)

1 ILM - Institut Lumière Matière [Villeurbanne]
2 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
3 CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant
4 Cynbiose

In this article, we report the safety evaluation of gadolinium-based nanoparticles in nonhuman primates (NHP) in the context of magnetic resonance imaging (MRI) studies in atherosclerosis bearing animals and healthy controls. In healthy NHP, the pharmacokinetics and toxicity profiles demonstrated the absence of dose, time, and sex-effects, as well as a suitable tolerance of intravenous administration of the nanoparticles. We investigated their imaging properties for arterial plaque imaging in a standard diet or a high cholesterol diet NHP, and compared their characteristics with clinically applied Gd-chelate. This preliminary investigation reports the efficient and safe imaging of atherosclerotic plaques.

Domaines: Imagerie

Shady Kotb, Joao Piraquive, Franck Lamberton, François Lux, Michael Verset, et al.. Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates. Scientific Reports, 2016, 6, pp.35053. ⟨10.1038/srep35053⟩. ⟨hal-01400103⟩