Mathematical modeling of tumor and metastatic growth when treated with sunitinib

Simon Evain 1, 2 Sebastien Benzekry 3, 2
2 MONC - Modélisation Mathématique pour l'Oncologie
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, Institut Bergonié - CRLCC Bordeaux
Abstract : The effect of the antiangiogenic drug sunitinib on the tumor size and the metastatic burden evolution are studied statistically and mathematically. For this, a new model SunitinibTGI is built, which allows to model with accuracy the phenomenon, thus giving us more information on the behavior of a tumor treated with sunitinib, distinguishing a phase of resistance to sunitinib under certain conditions. Together with some correlations that are noted on the data set, these tools allow us to better understand the metastatic response to sunitinib administration, notably in a neoadjuvant setting.
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Submitted on : Saturday, October 8, 2016 - 12:03:57 PM
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Simon Evain, Sebastien Benzekry. Mathematical modeling of tumor and metastatic growth when treated with sunitinib. [Research Report] Inria Bordeaux Sud-Ouest. 2016. ⟨hal-01377994⟩

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