Negative Events in Childhood Predict Trajectories of Internalizing Symptoms Up to Young Adulthood: An 18-Year Longitudinal Study

Maria Melchior (1) , Evelyne Touchette (2) , Elena Prokofyeva (1) , Aude Chollet (1) , Eric Fombonne (3) , Gulizar Elidemir (1) , Cédric Galera (4)

1 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
2 GRIP - Groupe de Recherche en Inadaptation Psychosociale
3 OHSU - Oregon Health and Science University [Portland]
4 Pédopsychiatrie universitaire, INSERM U897 [CHU CHarles Perrens]

Background: Common negative events can precipitate the onset of internalizing symptoms. We studied whether their occurrence in childhood is associated with mental health trajectories over the course of development. Methods: Using data from the TEMPO study, a French community-based cohort study of youths, we studied the association between negative events in 1991 (when participants were aged 4–16 years) and internalizing symptoms, assessed by the ASEBA family of instruments in 1991, 1999, and 2009 (n51503). Participants' trajectories of internalizing symptoms were estimated with semi-parametric regression methods (PROC TRAJ). Data were analyzed using multinomial regression models controlled for participants' sex, age, parental family status, socioeconomic position, and parental history of depression. Negative childhood events were associated with an increased likelihood of concurrent internalizing symptoms which sometimes persisted into adulthood (multivariate ORs associated with > = 3 negative events respectively: high and decreasing internalizing symptoms: 5.54, 95% CI: 3.20–9.58; persistently high internalizing symptoms: 8.94, 95% CI: 2.82–28.31). Specific negative events most strongly associated with youths' persistent internalizing symptoms included: school difficulties (multivariate OR: 5.31, 95% CI: 2.24–12.59), parental stress (multivariate OR: 4.69, 95% CI: 2.02–10.87), serious illness/health problems (multivariate OR: 4.13, 95% CI: 1.76–9.70), and social isolation (multivariate OR: 2.24, 95% CI: 1.00–5.08). Conclusions : Common negative events can contribute to the onset of children's lasting psychological difficulties.

Domains: Santé publique et épidémiologie

Maria Melchior, Evelyne Touchette, Elena Prokofyeva, Aude Chollet, Eric Fombonne, et al.. Negative Events in Childhood Predict Trajectories of Internalizing Symptoms Up to Young Adulthood: An 18-Year Longitudinal Study. PLoS ONE, 2014, 9 (12), pp.e114526. ⟨10.1371/journal.pone.0114526⟩. ⟨hal-01367438⟩