Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles

Abstract : Hydrophilic nanogels based on partially hydrolyzed poly(2-ethyl-2-oxazoline) were synthesized in dilute aqueous media in the presence of 1,6-hexanediol diglycidyl ether as a cross-linker. Nanogel formation was monitored by DLS and HSQC NMR spectroscopy, and the final nano-objects were characterized by DLS, TEM, AFM, and NanoSight analyses. Nanogels with a hydrodynamic radius of 78 nm exhibiting a slight positive surface charge were obtained. MTS assays (cell metabolic activity test) evidenced that nanogels were nontoxic in the investigated concentration range (i.e., 0.1 to 400 mu g/mL) and that no specific interaction with bovine serum albumin was observed.
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https://hal.archives-ouvertes.fr/hal-01361917
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Submitted on : Wednesday, September 7, 2016 - 5:23:18 PM
Last modification on : Thursday, January 11, 2018 - 6:28:10 AM

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Camille Legros, Anne-Laure Wirotius, Marie-Claire de Pauw-Gillet, Kam Chiu Tam, Daniel Taton, et al.. Poly(2-oxazoline)-Based Nanogels as Biocompatible Pseudopolypeptide Nanoparticles . Biomacromolecules, American Chemical Society, 2015, 16 (1), pp.183-191. ⟨10.1021/bm501393q ⟩. ⟨hal-01361917⟩

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