Aldehyde-functional copolymers based on poly(2-oxazoline) for post-polymerization modification

Abstract : Protected and non-protected homopolymers and related statistical copolymers based on poly(2-oxazoline) were synthesized by cationic ring-opening (co)polymerization, using a protected aldehyde 2-oxazoline monomer, namely, 2-[3-(1,3)-dioxolan-2-ylpropyl]-2-oxazoline (DPOx). The (co)polymer precursors were subsequently used as reactive platforms enabling the synthesis of miscellaneous derivatives, including graft and crosslinked copoly(2-oxazoline)s. Aldehyde-functional (co)polymers were first reacted with mono- or bi-functional amino- and hydrazido-containing reagents, forming grafted copolymers or chemically cross-linked networks, respectively. The latter compound consisting of hydrazone-type linkages formed hydrogels that could be slowly degraded at physiological pH over 3 days, but be readily cleaved in a more acidic environment (pH = 3). Aldehyde-containing (co)polymers were also found to be subjected to an intermolecular self-aldolization reaction under acidic conditions, leading to branchings and ultimately to the formation of dense 3D-networks.
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https://hal.archives-ouvertes.fr/hal-01361866
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Submitted on : Wednesday, September 7, 2016 - 4:27:51 PM
Last modification on : Thursday, January 11, 2018 - 6:28:10 AM

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Camille Legros, Marie-Claire de Pauw-Gillet, Kam Chiu Tam, Sébastien Lecommandoux, Daniel Taton. Aldehyde-functional copolymers based on poly(2-oxazoline) for post-polymerization modification . European Polymer Journal, Elsevier, 2015, 62, pp.322-330. ⟨10.1016/j.eurpolymj.2014.08.026⟩. ⟨hal-01361866⟩

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