A prototype reversible polymersome-stabilized H2S photoejector operating under pseudophysiological conditions

Arnaud Tron (1) , Ariane Peyret (2, 3) , Julie Thevenot (2, 3) , Robin Bofinger (1) , Sébastien Lecommandoux (2, 3) , Nathan D. Mcclenaghan (1)

1 ISM - Institut des Sciences Moléculaires
2 LCPO - Laboratoire de Chimie des Polymères Organiques
3 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Persistent self-assembled polymersome capsules are shown to solubilise and stabilize a new hydrosulfide-containing (2), as well as hydroxylated (1), malachite green derivatives in their leuco-forms in aqueous buffer solution. Photoirradiation resulted in reversible hydroxide release/hydrogen sulfide generation. Notably, the efficient augmentation of H2S concentration to physiologically-relevant levels is shown.

Mots clés: CHEMISTRY; PROBE; HYDROGEN-SULFIDE; LIVING CELLS; LIGHT; RELEASE; MECHANISMS

Domaines: Polymères

Arnaud Tron, Ariane Peyret, Julie Thevenot, Robin Bofinger, Sébastien Lecommandoux, et al.. A prototype reversible polymersome-stabilized H2S photoejector operating under pseudophysiological conditions. Organic & Biomolecular Chemistry, 2016, 14 (27), pp.6394-6397. ⟨10.1039/c6ob01155a⟩. ⟨hal-01360809⟩