What history tells us XXXIII. Molecular hybridization: A problematic tool for the study of differentiation and development (1960-1980)
Résumé
Molecular hybridization was widely used between 1960 and 1980. It was the unique molecular tool susceptible to provide information on the mechanisms of differentiation and development, before the advent of genetic engineering tools at the end of the 1970s. But the results of this technique were ambiguous, and generated plenty of speculations that were later abandoned. The technique did not allow to describe gene splicing, nor to demonstrate the insertion by reverse transcription of some RNA viruses into the cellular genome. I describe this forgotten episode of the history of molecular biology.
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