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Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet 1, 2 Josep M. Anto Peter J. Sterk Ian M. Adcock Kian Fan Chung Josep Roca Alvar Agusti Chris Brightling Anne Cambon-Thomsen 3 Alfredo Cesario Sonia Abdelhak 4 Stylianos E. Antonarakis Antoine Avignon 5 Andrea Ballabio Eugenio Baraldi Alexander Baranov Thomas Bieber 6 Joël Bockaert 7 Samir Brahmachari Christian Brambilla 8 Jacques Bringer Michel Dauzat Ingemar Ernberg Leonardo Fabbri Philippe Froguel 9 David Galas Takashi Gojobori Peter Hunter 10 Christian Jorgensen 11, 12 Francine Kauffmann 1 Philippe Kourilsky 13 Marek L. Kowalski Doron Lancet Claude Le Pen 14 Jacques Mallet 15 Bongani Mayosi Jacques Mercier 16 Andres Metspalu 17 Joseph H. Nadeau Gregory Ninot 18 Denis Noble Mehmet Ozturk 8 Susanna Palkonen Christian Préfaut 19, 20 Klaus Rabe 21 Eric Renard 22 Richard G. Roberts Boleslav Samolinski Holger J. Schuenemann Hans-Uwe Simon Marcelo Bento Soares Giulio Superti-Furga 23 Jesper Tegnér 24 Sergio Verjovski-Almeida 25 Peter Wellstead Olaf Wolkenhauer 26, 27 Emiel Wouters Rudi Balling Anthony J. Brookes 28 Dominique Charron 29 Christophe Pison 30 Zhu Chen Leroy Hood Charles Auffray 30, 31, 29
Abstract : We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specic complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specicities of local economies and health systems.
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Jean Bousquet, Josep M. Anto, Peter J. Sterk, Ian M. Adcock, Kian Fan Chung, et al.. Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Medicine, BioMed Central, 2011, 3, pp.43. ⟨10.1186/gm259⟩. ⟨hal-01358549⟩



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