Modeling Biology Spanning Different Scales: An Open Challenge

Filippo Castiglione (1) , Francesco Pappalardo (2) , Carlo Bianca (3) , Giulia Russo (2) , Santo Motta (2)

1 Institute for Applied Mathematics (IAC) CNR, Rome, Italy.
2 Unict - Università degli studi di Catania = University of Catania
3 LPTMC - Laboratoire de Physique Théorique de la Matière Condensée

It is coming nowadays more clear that in order to obtain a unified description of the different mechanisms governing the behavior and causality relations among the various parts of a living system, the development of comprehensive computational and mathematical models at different space and time scales is required. This is one of the most formidable challenges of modern biology characterized by the availability of huge amount of high throughput measurements. In this paper we draw attention to the importance of multiscale modeling in the framework of studies of biological systems in general and of the immune system in particular.

Domaines: Mathématiques [math]; Sciences du Vivant [q-bio]

Filippo Castiglione, Francesco Pappalardo, Carlo Bianca, Giulia Russo, Santo Motta. Modeling Biology Spanning Different Scales: An Open Challenge. BioMed Research International , 2014, 2014, pp.902545. ⟨10.1155/2014/902545⟩. ⟨hal-01308210⟩