Systemic sclerosis: An update in 2016

Anne Claire Desbois (1, 2) , Patrice Cacoub (2, 3)

1 CHU Saint-Antoine [AP-HP]
2 I3 - Immunologie - Immunopathologie - Immunothérapie
3 CHU Pitié-Salpêtrière [AP-HP]

Systemic sclerosis (SSc) is a chronic immune disorder of unknown origin, dominated by excessive fibrosis responsible for cutaneous and pulmonary fibrosis, and by vascular endothelial dysfunction at the origin of skin ischemia, renal and pulmonary artery lesions. Renal and pulmonary complications are mainly responsible for the severity of the disease. Recent advances led to a better understanding of pathological mechanisms and a more accurate classification of patients according to clinical and biological (auto-antibodies) phenotype. Recent trials provided interesting data on different therapeutic strategies, depending on organ involvement. These data are of particular importance in such disease, still characterized by increased mortality and morbidity rates. In this review, we aim to synthetize recent advances in diagnosis and prognosis leading to better classification of SSc patients, and in therapeutic management.

Mots clés: systemic sclerosis; autoimmune disease; treatment

Domaines: Génétique; Immunologie

Anne Claire Desbois, Patrice Cacoub. Systemic sclerosis: An update in 2016. Autoimmunity Reviews, 2016, 15 (5), pp.417-426. ⟨10.1016/j.autrev.2016.01.007⟩. ⟨hal-01297570⟩