Cerebellar sub-structures in cognitive impairment: volumetric and microstructural analyses at different stages of multiple sclerosis

Amadine Moroso (1) , Aurélie Ruet (2, 1) , Delphine Lamargue (3) , Fanny Munsch (4) , Mathilde Deloire (1) , Pierrick Coupé (5) , Jean-Christophe Ouallet (1) , Vincent Planche (4) , Nicolas Moscufo (6) , Dominik Meier (6) , Thomas Tourdias (2) , C. R. G. Guttmann (7) , Vincent Dousset (2) , Bruno Brochet (1, 4)

1 Service de neurologie [Bordeaux]
2 Neuroinflammation: imagerie et thérapie de la sclérose en plaques
3 Physiopathologie du système nerveux central - Institut François Magendie
4 UB - Université de Bordeaux
5 PICTURA - Patch-based processing for medical and natural images
6 Center for Neurological Imaging
7 Center for Neurological Imaging, Department of Radiology

Recent studies have demonstrated the impact of cerebellar lesion load and atrophy on cognitive impairment in multiple sclerosis (MS) that might result from functional disconnection in the fronto-cerebellar loop and local modulation. However, structural alterations in posterior lobules, in which cognitive functioning seems preponderant, are still unknown.

Domaines: Imagerie médicale

Amadine Moroso, Aurélie Ruet, Delphine Lamargue, Fanny Munsch, Mathilde Deloire, et al.. Cerebellar sub-structures in cognitive impairment: volumetric and microstructural analyses at different stages of multiple sclerosis. ECTRIMS, Oct 2015, Barcelona, Spain. pp.365. ⟨hal-01290690⟩