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Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

Abstract : Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins acquires high-affinity reactivity with the antigenic domain-III of JEV E glycoprotein. These JEV-reactive antibodies exhibited neutralizing activity against recently dominant JEV genotypes. This study opens new therapeutic options for Japanese encephalitis.
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Nimesh Gupta, Mélissanne de Wispelaere, Maxime Lecerf, Manjula Kalia, Tobias Scheel, et al.. Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody. Scientific Reports, Nature Publishing Group, 2015, 5, pp.16248. ⟨10.1038/srep16248⟩. ⟨hal-01272042⟩

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