Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

Abstract : Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins acquires high-affinity reactivity with the antigenic domain-III of JEV E glycoprotein. These JEV-reactive antibodies exhibited neutralizing activity against recently dominant JEV genotypes. This study opens new therapeutic options for Japanese encephalitis.
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Scientific Reports, Nature Publishing Group, 2015, 5, pp.16248. <10.1038/srep16248>
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Dernière modification le : lundi 29 mai 2017 - 15:34:27

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Nimesh Gupta, Mélissanne De Wispelaere, Maxime Lecerf, Manjula Kalia, Tobias Scheel, et al.. Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody. Scientific Reports, Nature Publishing Group, 2015, 5, pp.16248. <10.1038/srep16248>. <hal-01272042>

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