An amphiphilic PEG-b-PFPE-b-PEG triblock copolymer: synthesis by CuAAC click chemistry and self-assembly in water

Gerald Lopez (1) , Marc Guerre (1) , Judith Schmidt (2) , Ishi Talmon, (2) , Vincent Ladmiral (1) , Jean-Pierre Habas (1) , Bruno Ameduri (1)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 Technion - Israel Institute of Technology [Haifa]

A new PEG2000-b-PFPE1200-b-PEG2000 amphiphilic triblock copolymer was synthesized by copper(I)- catalyzed alkyne–azide cycloaddition (CuAAC). The microstructure of this ABA triblock copolymer was unequivocally characterized by NMR spectroscopy. Diffusion-ordered spectroscopy (DOSY) NMR experiment revealed that 1H resonances belonging to PEG and PFPE are aligned on the same horizontal line, thus implying that all these signals are due to the same macromolecule whose diffusion coefficient is lower than that of PEG and PFPE homopolymers. Thanks to its semi-fluorinated backbone bearing robust triazole rings, the PEG2000-b-PFPE1200-b-PEG2000 triblock copolymer exhibits good thermal stability with no significant weight loss until 275 °C under air. This triblock copolymer undergoes self-assembly into micelles (D = 10–20 nm) in aqueous solution as confirmed from cryogenic-temperature transmission electron microscopy, DOSY experiment in D2O, and dynamic light scattering. The critical micelle concentration was determined by pyrene fluorescence assay, and was found to be 0.1 mg mL−1.

Mots clés: fluoropolymers; triblock copolymers; DLS; Diffusion-ordered spectroscopy; NMR; tehrmalstability; catalyzed alkyne–azide cycloaddition

Domaines: Polymères

Gerald Lopez, Marc Guerre, Judith Schmidt, Ishi Talmon,, Vincent Ladmiral, et al.. An amphiphilic PEG-b-PFPE-b-PEG triblock copolymer: synthesis by CuAAC click chemistry and self-assembly in water. Polymer Chemistry, 2016, 7, pp.402-409. ⟨10.1039/c5py01621e⟩. ⟨hal-01257791⟩