Plasma antitumor action and the potential role of plasma-induced electric fields

Abstract : After a brief review of the main progress in the plasma cancer domain, experiments dealing with cancer treatment ran by the Orleans group with DBD and, mainly, with the Plasma Gun in different setups will be presented. From the first in vivo demonstration of air DBD plasma antitumor effect, antitumor action with helium or neon fed plasma jets delivered in ambient air on different tumor bearing organs in mice have been achieved. The positive combination of plasma jet treatment with chemotherapeutic agents was also demonstrated on pancreatic tumors [1]. The reasons for this positive combination are under study to suggest new combined protocols likely to promote the antitumor action of plasma jets and afford a new adjuvant approach for cancer treatment. Both loco regional plasma-induced tumor environment oxygenation and blood flow modulation, as recently demonstrated for healthy mice [2], and the potential role of intense transient electric fields associated with plasma delivery over targets, are under study. The synchronized in situ delivery of so called ROS/RNS and transient electric fields may be a unique feature of plasma treatments likely to involve either electroporation or chemical agents but also their combined action. First measurements, including the temporal profile and intensity, of the electric field associated with plasma jets delivery over different targets will be presented. Brullé et al, Plos one, 2012, 7 (12) e52653. Collet et al, Plasma Sources Sci. Technol., 2014, 23 012005 Keywords: plasma medicine, electric fields, antitumor action, plasma jet.
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Submitted on : Tuesday, January 12, 2016 - 5:03:29 PM
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Eric Robert, Guillaume Collet, Laura Brullé, Thibault Darny, Claudine Kieda, et al.. Plasma antitumor action and the potential role of plasma-induced electric fields. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, Food and Environmental Technologies IWEPEF, ISEBTT, Sep 2015, Portoroz, Slovenia. ⟨hal-01254848⟩

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