Divergent Gemycircularvirus in HIV-Positive Blood, France.

Rathviro Uch (1, 2) , Pierre-Edouard Fournier (3, 4) , Catherine Robert , Caroline Blanc-Tailleur , Vital Galicher (1, 2) , Romain Barre (1, 2) , François Jordier (1, 2) , Philippe de Micco (1, 2, 3) , Didier Raoult (3, 5) , Philippe Biagini (1, 2, 3)

1 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
2 EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée
3 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
4 VITROME - Vecteurs - Infections tropicales et méditerranéennes
5 MEPHI - Microbes évolution phylogénie et infections

We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.

Domaines: Hématologie; Virologie; Sciences du Vivant [q-bio]

Rathviro Uch, Pierre-Edouard Fournier, Catherine Robert, Caroline Blanc-Tailleur, Vital Galicher, et al.. Divergent Gemycircularvirus in HIV-Positive Blood, France.. Emerging Infectious Diseases, 2015, 21 (11), pp.2096-8. ⟨10.3201/eid2111.150486⟩. ⟨hal-01235994⟩