microwave-enhanced grafting of peptides inside metal-organic framework

J. Canivet (1) , J. Bonnefoy (1) , E.A. Quadrelli , D. Farrusseng (1)

1 ING - IRCELYON-Ingéniérie, du matériau au réacteur

Grafting of chiral species such as amino-acids or peptides inside MOF cavities allows designing bio-functional materials and the covalent post-synthetic modification is a tool of choice to increase the sophistication degree in porous materials. We will present the synthesis of oligopeptides-functionalized MOFs following a methodology tightly integrating molecular modeling and experimental work. Solid phase peptide coupling strategy is applied to different MOF topologies (UiO, MIL-68 and MIL-101) in order to immobilize up to tetrapeptide chains inside amino-functionalized frameworks. This new microwave-based methodology allows reaction times shortening, from days to minutes, and higher grafting yields (up to 60% of amino groups converted) without racemization of the chiral peptide grafts. This fast and easy methods allows designing library of functional hybrid materials for high value added applications such as sensing, separation and asymmetric catalysis.

Domaines: Catalyse; Environnement et Société

J. Canivet, J. Bonnefoy, E.A. Quadrelli, D. Farrusseng. microwave-enhanced grafting of peptides inside metal-organic framework. EuroMOF 2015 - 1st European Conference on Metal Organic Frameworks and Porous Polymers, Oct 2015, Potsdam, Germany. ⟨hal-01214467⟩