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Methylene blue phosphoramidite for DNA labelling

Abstract : We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochemical and optical properties of the resulting MB modified oligonucleotides were confirmed. This new molecule is an important breakthrough in the design of new probes labelled with MB.
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https://hal.archives-ouvertes.fr/hal-01187184
Contributor : Agnès Bussy <>
Submitted on : Wednesday, August 26, 2015 - 12:16:47 PM
Last modification on : Friday, April 17, 2020 - 5:16:02 PM

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Gabriel de Crozals, Carole Farre, Monique Sigaud, Philippe Fortgang, Corinne Sanglar, et al.. Methylene blue phosphoramidite for DNA labelling. Chemical Communications, Royal Society of Chemistry, 2015, 51 (21), pp.4458-4461. ⟨10.1039/c4cc10164b⟩. ⟨hal-01187184⟩

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