Methylene blue phosphoramidite for DNA labelling

Gabriel de Crozals 1 Carole Farre 1 Monique Sigaud 2 Philippe Fortgang 1 Sanglar Corinne 3 Chaix Carole 1
1 Interfaces & biosensors - Interfaces & biocapteurs
ISA - Institut des Sciences Analytiques
2 Micro & Nanobiotechnologies
ISA - Institut des Sciences Analytiques
3 INTERACT - Interactions biomoléculaires
ISA - Institut des Sciences Analytiques
Abstract : We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochemical and optical properties of the resulting MB modified oligonucleotides were confirmed. This new molecule is an important breakthrough in the design of new probes labelled with MB.
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https://hal.archives-ouvertes.fr/hal-01187184
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Submitted on : Wednesday, August 26, 2015 - 12:16:47 PM
Last modification on : Thursday, February 8, 2018 - 11:10:30 AM

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Gabriel De Crozals, Carole Farre, Monique Sigaud, Philippe Fortgang, Sanglar Corinne, et al.. Methylene blue phosphoramidite for DNA labelling. Chemical Communications, Royal Society of Chemistry, 2015, 51 (21), pp.4458-4461. 〈10.1039/c4cc10164b〉. 〈hal-01187184〉

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