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The role of LARP1 in translation and beyond.

Abstract : The LARP1 proteins form an evolutionarily homogeneous subgroup of the eukaryotic superfamily of La-Motif (LAM) containing factors. Members of the LARP1 family are found in most protists, fungi, plants, and animals. We review here evidence suggesting that LARP1 are key versatile messenger RNA (mRNA)-binding proteins involved in regulating important biological processes such as gametogenesis, embryogenesis, sex determination, and cell division in animals, as well as acclimation to stress in yeasts and plants. LARP1 proteins perform all these essential tasks likely by binding to key mRNAs and regulating their stability and/or translation. In human, the impact of LARP1 over cell division and proliferation is potentially under the control of the TORC1 complex. We review data suggesting that LARP1 is a direct target of this master signaling hub. TOR-dependent LARP1 phosphorylation could specifically enhance the translation of TOP mRNAs providing a way to promote translation, growth, and proliferation. Consequently, LARP1 is found to be significantly upregulated in many malignant cell types. In plants, LARP1 was found to act as a cofactor of the heat-induced mRNA degradation process, an essential acclimation strategy leading to the degradation of more than 4500 mRNAs coding for growth and development housekeeping functions. In Saccharomyces cerevisiae, the LARP1 proteins (Slf1p and Sro9p) are important, among other things, for copper resistance and oxidative stress survival. LARP1 proteins are therefore emerging as critical ancient mRNA-binding factors that evolved common as well as specific targets and regulatory functions in all eukaryotic lineages. WIREs RNA 2015, 6:399-417. doi: 10.1002/wrna.1282 For further resources related to this article, please visit the WIREs website. The authors have declared no conflicts of interest for this article.
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https://hal.archives-ouvertes.fr/hal-01180125
Contributor : Elisabeth Goetschy <>
Submitted on : Friday, July 24, 2015 - 12:03:45 PM
Last modification on : Thursday, January 11, 2018 - 6:25:25 AM

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  • HAL Id : hal-01180125, version 1
  • PUBMED : 25892282

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Jean-Marc Deragon, Cécile Bousquet-Antonelli. The role of LARP1 in translation and beyond.. Wiley Interdisciplinary Reviews: RNA, Wiley, 2015, 6 (4), pp.399-417. ⟨hal-01180125⟩

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