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Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction – Formulation and preliminary results

Abstract : We propose a muscle chemo-mechanical model by which cross-bridges in sarcomeres are considered as special chemical entities having internal mechanical variables pertaining to the actual geometric configuration. This provides a thermodynamical basis for modeling the complex interplay of chemical and mechanical phenomena at the sarcomere level. Important motivations for this modeling choice include the ability to represent (i) the so-called power-stroke phenomenon and (ii) short-time responses of a muscle, e.g. to load steps, and we will present some corresponding numerical simulations.
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https://hal.archives-ouvertes.fr/hal-01180005
Contributor : Matthieu Caruel <>
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  • HAL Id : hal-01180005, version 1

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Matthieu Caruel, Philippe Moireau, Dominique Chapelle. Thermodynamical framework for modeling chemo-mechanical coupling in muscle contraction – Formulation and preliminary results. 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015, Jun 2015, Paris, France. ⟨hal-01180005⟩

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