Mechanistic Studies of Gd3+-Based MRI Contrast Agents for Zn2+ Detection: Towards Rational Design

Abstract : A series of novel pyridine-based Gd3+ complexes have been prepared and studied as potential MRI contrast agents for Zn2+ detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn2+ binding in terms of variations of the rotational motion.
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Submitted on : Monday, July 20, 2015 - 10:30:20 AM
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Célia S. Bonnet, Fabien Caillé, Agnès Pallier, Jean-François Morfin, Stéphane Petoud, et al.. Mechanistic Studies of Gd3+-Based MRI Contrast Agents for Zn2+ Detection: Towards Rational Design. Chemistry - A European Journal, Wiley-VCH Verlag, 2014, 20 (35), pp.10959-10969. ⟨10.1002/chem.201403043⟩. ⟨hal-01178456⟩

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